Interhemispheric functional connectivity and its relationships with clinical characteristics in major depressive disorder: a resting state fMRI study
Abnormalities in large-scale, structural and functional brain connectivity have been increasingly reported in patients with major depressive disorder (MDD). However, MDD-related alterations in functional interaction between the cerebral hemispheres are still not well understood. Resting state fMRI,...
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| Veröffentlicht in: | PloS one 2013-03, Vol.8 (3), p.e60191 |
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| creator | Wang, Li Li, Ke Zhang, Qing-E Zeng, Ya-Wei Jin, Zhen Dai, Wen-Ji Su, Yun-Ai Wang, Gang Tan, Yun-Long Yu, Xin Si, Tian-Mei |
| description | Abnormalities in large-scale, structural and functional brain connectivity have been increasingly reported in patients with major depressive disorder (MDD). However, MDD-related alterations in functional interaction between the cerebral hemispheres are still not well understood. Resting state fMRI, which reveals spontaneous neural fluctuations in blood oxygen level dependent signals, provides a means to detect interhemispheric functional coherence. We examined the resting state functional connectivity (RSFC) between the two hemispheres and its relationships with clinical characteristics in MDD patients using a recently proposed measurement named "voxel-mirrored homotopic connectivity (VMHC)".
We compared the interhemispheric RSFC, computed using the VMHC approach, of seventeen first-episode drug-naive patients with MDD and seventeen healthy controls. Compared to the controls, MDD patients showed significant VMHC decreases in the medial orbitofrontal gyrus, parahippocampal gyrus, fusiform gyrus, and occipital regions including the middle occipital gyrus and cuneus. In MDD patients, a negative correlation was found between VMHC of the fusiform gyrus and illness duration. Moreover, there were several regions whose VMHC showed significant negative correlations with the severity of cognitive disturbance, including the prefrontal regions, such as middle and inferior frontal gyri, and two regions in the cereballar crus.
These findings suggest that the functional coordination between homotopic brain regions is impaired in MDD patients, thereby providing new evidence supporting the interhemispheric connectivity deficits of MDD. The significant correlations between the VMHC and clinical characteristics in MDD patients suggest potential clinical implication of VMHC measures for MDD. Interhemispheric RSFC may serve as a useful screening method for evaluating MDD where neural connectivity is implicated in the pathophysiology. |
| doi_str_mv | 10.1371/journal.pone.0060191 |
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We compared the interhemispheric RSFC, computed using the VMHC approach, of seventeen first-episode drug-naive patients with MDD and seventeen healthy controls. Compared to the controls, MDD patients showed significant VMHC decreases in the medial orbitofrontal gyrus, parahippocampal gyrus, fusiform gyrus, and occipital regions including the middle occipital gyrus and cuneus. In MDD patients, a negative correlation was found between VMHC of the fusiform gyrus and illness duration. Moreover, there were several regions whose VMHC showed significant negative correlations with the severity of cognitive disturbance, including the prefrontal regions, such as middle and inferior frontal gyri, and two regions in the cereballar crus.
These findings suggest that the functional coordination between homotopic brain regions is impaired in MDD patients, thereby providing new evidence supporting the interhemispheric connectivity deficits of MDD. The significant correlations between the VMHC and clinical characteristics in MDD patients suggest potential clinical implication of VMHC measures for MDD. Interhemispheric RSFC may serve as a useful screening method for evaluating MDD where neural connectivity is implicated in the pathophysiology.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0060191</identifier><identifier>PMID: 23555920</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adult ; Biology ; Brain ; Brain mapping ; Brain research ; Case-Control Studies ; Cerebral hemispheres ; Cerebrum - physiology ; Cerebrum - physiopathology ; Cognitive ability ; Correlation ; Depressive Disorder, Major - physiopathology ; Emotions ; Ethics ; Female ; Functional magnetic resonance imaging ; Humans ; Laboratories ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Medicine ; Memory ; Mental depression ; Mental health ; Middle Aged ; Neural networks ; Neurobiology ; NMR ; Nuclear magnetic resonance ; Oxygen ; Parahippocampal gyrus ; Patients ; Psychiatry ; Structure-function relationships ; Studies ; Systematic review ; Variation ; Young Adult</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e60191</ispartof><rights>2013 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Wang et al 2013 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-d3f9eb4e70ca79e67f6be907fcc616ff626c2bf04032e45af80a81b126bb988b3</citedby><cites>FETCH-LOGICAL-c526t-d3f9eb4e70ca79e67f6be907fcc616ff626c2bf04032e45af80a81b126bb988b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612036/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612036/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23555920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Zhang, Qing-E</creatorcontrib><creatorcontrib>Zeng, Ya-Wei</creatorcontrib><creatorcontrib>Jin, Zhen</creatorcontrib><creatorcontrib>Dai, Wen-Ji</creatorcontrib><creatorcontrib>Su, Yun-Ai</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><creatorcontrib>Tan, Yun-Long</creatorcontrib><creatorcontrib>Yu, Xin</creatorcontrib><creatorcontrib>Si, Tian-Mei</creatorcontrib><title>Interhemispheric functional connectivity and its relationships with clinical characteristics in major depressive disorder: a resting state fMRI study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Abnormalities in large-scale, structural and functional brain connectivity have been increasingly reported in patients with major depressive disorder (MDD). However, MDD-related alterations in functional interaction between the cerebral hemispheres are still not well understood. Resting state fMRI, which reveals spontaneous neural fluctuations in blood oxygen level dependent signals, provides a means to detect interhemispheric functional coherence. We examined the resting state functional connectivity (RSFC) between the two hemispheres and its relationships with clinical characteristics in MDD patients using a recently proposed measurement named "voxel-mirrored homotopic connectivity (VMHC)".
We compared the interhemispheric RSFC, computed using the VMHC approach, of seventeen first-episode drug-naive patients with MDD and seventeen healthy controls. Compared to the controls, MDD patients showed significant VMHC decreases in the medial orbitofrontal gyrus, parahippocampal gyrus, fusiform gyrus, and occipital regions including the middle occipital gyrus and cuneus. In MDD patients, a negative correlation was found between VMHC of the fusiform gyrus and illness duration. Moreover, there were several regions whose VMHC showed significant negative correlations with the severity of cognitive disturbance, including the prefrontal regions, such as middle and inferior frontal gyri, and two regions in the cereballar crus.
These findings suggest that the functional coordination between homotopic brain regions is impaired in MDD patients, thereby providing new evidence supporting the interhemispheric connectivity deficits of MDD. The significant correlations between the VMHC and clinical characteristics in MDD patients suggest potential clinical implication of VMHC measures for MDD. Interhemispheric RSFC may serve as a useful screening method for evaluating MDD where neural connectivity is implicated in the pathophysiology.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Biology</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Cerebral hemispheres</subject><subject>Cerebrum - physiology</subject><subject>Cerebrum - physiopathology</subject><subject>Cognitive ability</subject><subject>Correlation</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Emotions</subject><subject>Ethics</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Memory</subject><subject>Mental depression</subject><subject>Mental health</subject><subject>Middle Aged</subject><subject>Neural networks</subject><subject>Neurobiology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxygen</subject><subject>Parahippocampal gyrus</subject><subject>Patients</subject><subject>Psychiatry</subject><subject>Structure-function relationships</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Variation</subject><subject>Young 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Li</au><au>Li, Ke</au><au>Zhang, Qing-E</au><au>Zeng, Ya-Wei</au><au>Jin, Zhen</au><au>Dai, Wen-Ji</au><au>Su, Yun-Ai</au><au>Wang, Gang</au><au>Tan, Yun-Long</au><au>Yu, Xin</au><au>Si, Tian-Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interhemispheric functional connectivity and its relationships with clinical characteristics in major depressive disorder: a resting state fMRI study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-03-29</date><risdate>2013</risdate><volume>8</volume><issue>3</issue><spage>e60191</spage><pages>e60191-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Abnormalities in large-scale, structural and functional brain connectivity have been increasingly reported in patients with major depressive disorder (MDD). However, MDD-related alterations in functional interaction between the cerebral hemispheres are still not well understood. Resting state fMRI, which reveals spontaneous neural fluctuations in blood oxygen level dependent signals, provides a means to detect interhemispheric functional coherence. We examined the resting state functional connectivity (RSFC) between the two hemispheres and its relationships with clinical characteristics in MDD patients using a recently proposed measurement named "voxel-mirrored homotopic connectivity (VMHC)".
We compared the interhemispheric RSFC, computed using the VMHC approach, of seventeen first-episode drug-naive patients with MDD and seventeen healthy controls. Compared to the controls, MDD patients showed significant VMHC decreases in the medial orbitofrontal gyrus, parahippocampal gyrus, fusiform gyrus, and occipital regions including the middle occipital gyrus and cuneus. In MDD patients, a negative correlation was found between VMHC of the fusiform gyrus and illness duration. Moreover, there were several regions whose VMHC showed significant negative correlations with the severity of cognitive disturbance, including the prefrontal regions, such as middle and inferior frontal gyri, and two regions in the cereballar crus.
These findings suggest that the functional coordination between homotopic brain regions is impaired in MDD patients, thereby providing new evidence supporting the interhemispheric connectivity deficits of MDD. The significant correlations between the VMHC and clinical characteristics in MDD patients suggest potential clinical implication of VMHC measures for MDD. Interhemispheric RSFC may serve as a useful screening method for evaluating MDD where neural connectivity is implicated in the pathophysiology.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23555920</pmid><doi>10.1371/journal.pone.0060191</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Adult Biology Brain Brain mapping Brain research Case-Control Studies Cerebral hemispheres Cerebrum - physiology Cerebrum - physiopathology Cognitive ability Correlation Depressive Disorder, Major - physiopathology Emotions Ethics Female Functional magnetic resonance imaging Humans Laboratories Magnetic Resonance Imaging - methods Male Medical imaging Medicine Memory Mental depression Mental health Middle Aged Neural networks Neurobiology NMR Nuclear magnetic resonance Oxygen Parahippocampal gyrus Patients Psychiatry Structure-function relationships Studies Systematic review Variation Young Adult |
| title | Interhemispheric functional connectivity and its relationships with clinical characteristics in major depressive disorder: a resting state fMRI study |
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