Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy
Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in ou...
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| Veröffentlicht in: | PloS one 2013-03, Vol.8 (3), p.e59215-e59215 |
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| creator | Sierra, Josep M Camoez, Mariana Tubau, Fe Gasch, Oriol Pujol, Miquel Martin, Rogelio Domínguez, M Angeles |
| description | Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance. |
| doi_str_mv | 10.1371/journal.pone.0059215 |
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Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0059215</identifier><identifier>PMID: 23554998</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acetamides - therapeutic use ; Aged ; Anti-Bacterial Agents - therapeutic use ; Bacterial Proteins - metabolism ; Biology ; Case reports ; Clinical isolates ; Clinical medicine ; Cloning ; Drug resistance ; Drug Resistance, Multiple, Bacterial ; Epidemics ; Genes ; Hospitals ; Humans ; Infeccions respiratòries ; Infectious diseases ; Intensive care ; Intensive care units ; Linezolid ; Male ; Medicine ; Methicillin ; Methicillin - therapeutic use ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Methicillin-Resistant Staphylococcus aureus - metabolism ; Microbial drug resistance ; Microbial Sensitivity Tests ; Microbiology ; Mutation ; Oxazolidinones - therapeutic use ; Pathology ; Patients ; Respiratory infections ; Spain ; Staphylococcal infections ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus infections ; Therapy ; Unitats de cures intensives</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e59215-e59215</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Sierra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>cc-by (c) Sierra, J.M. et al., 2013 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a></rights><rights>2013 Sierra et al 2013 Sierra et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c734t-3a5e00df240786a743378076aba4b40617da4bf54b8c5c77744547a62e98f9673</citedby><cites>FETCH-LOGICAL-c734t-3a5e00df240786a743378076aba4b40617da4bf54b8c5c77744547a62e98f9673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598648/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598648/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,26951,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23554998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rohde, Holger</contributor><creatorcontrib>Sierra, Josep M</creatorcontrib><creatorcontrib>Camoez, Mariana</creatorcontrib><creatorcontrib>Tubau, Fe</creatorcontrib><creatorcontrib>Gasch, Oriol</creatorcontrib><creatorcontrib>Pujol, Miquel</creatorcontrib><creatorcontrib>Martin, Rogelio</creatorcontrib><creatorcontrib>Domínguez, M Angeles</creatorcontrib><title>Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). 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Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.</description><subject>Acetamides - therapeutic use</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial Proteins - metabolism</subject><subject>Biology</subject><subject>Case reports</subject><subject>Clinical isolates</subject><subject>Clinical medicine</subject><subject>Cloning</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Epidemics</subject><subject>Genes</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infeccions respiratòries</subject><subject>Infectious diseases</subject><subject>Intensive care</subject><subject>Intensive care units</subject><subject>Linezolid</subject><subject>Male</subject><subject>Medicine</subject><subject>Methicillin</subject><subject>Methicillin - therapeutic use</subject><subject>Methicillin-Resistant Staphylococcus aureus - 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Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23554998</pmid><doi>10.1371/journal.pone.0059215</doi><tpages>e59215</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetamides - therapeutic use Aged Anti-Bacterial Agents - therapeutic use Bacterial Proteins - metabolism Biology Case reports Clinical isolates Clinical medicine Cloning Drug resistance Drug Resistance, Multiple, Bacterial Epidemics Genes Hospitals Humans Infeccions respiratòries Infectious diseases Intensive care Intensive care units Linezolid Male Medicine Methicillin Methicillin - therapeutic use Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - isolation & purification Methicillin-Resistant Staphylococcus aureus - metabolism Microbial drug resistance Microbial Sensitivity Tests Microbiology Mutation Oxazolidinones - therapeutic use Pathology Patients Respiratory infections Spain Staphylococcal infections Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus infections Therapy Unitats de cures intensives |
| title | Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy |
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