Comprehensive characterization of human genome variation by high coverage whole-genome sequencing of forty four Caucasians

Whole genome sequencing studies are essential to obtain a comprehensive understanding of the vast pattern of human genomic variations. Here we report the results of a high-coverage whole genome sequencing study for 44 unrelated healthy Caucasian adults, each sequenced to over 50-fold coverage (avera...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e59494
Hauptverfasser:	Shen, Hui, Li, Jian, Zhang, Jigang, Xu, Chao, Jiang, Yan, Wu, Zikai, Zhao, Fuping, Liao, Li, Chen, Jun, Lin, Yong, Tian, Qing, Papasian, Christopher J, Deng, Hong-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Analysis Antigen processing Bioinformatics Biological activity Biological effects Biology Chromosomes, Human, Y - genetics Computer Science Consortia Deoxyribonucleic acid Disease - ethnology Disease - genetics DNA DNA Copy Number Variations - genetics DNA sequencing DNA, Mitochondrial - genetics Female Gene frequency Gene sequencing Genes Genetic aspects Genetic diversity Genetic research Genetic testing Genome, Human - genetics Genomes Genomics Health care Humans Immune response Immune system INDEL Mutation - genetics Male Medicine Mitochondrial DNA Mutation Rate Polymorphism, Single Nucleotide - genetics Public health Science Sequence Analysis, DNA - methods Single nucleotide polymorphisms Single-nucleotide polymorphism Studies White People - genetics
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