Investigation of the spatiotemporal responses of nanoparticles in tumor tissues with a small-scale mathematical model

The transport and accumulation of anticancer nanodrugs in tumor tissues are affected by many factors including particle properties, vascular density and leakiness, and interstitial diffusivity. It is important to understand the effects of these factors on the detailed drug distribution in the entire...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e59135
Hauptverfasser:	Chou, Cheng-Ying, Huang, Chih-Kang, Lu, Kuo-Wei, Horng, Tzyy-Leng, Lin, Win-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Angiogenesis Antineoplastic agents Applied mathematics Area Under Curve Binding sites Biological effects Biological Transport Biology Biomedical engineering Blood vessels Cancer cells Cancer therapies Capillary Permeability Carrier lifetime Chemotherapy Computer Simulation Dextrans Dextrans - metabolism Dextrans - pharmacokinetics Diffusivity Dosage and administration Drug Delivery Systems Engineering Engineering research Exposure Extracellular matrix Growth factors Half life Humans Macromolecular Substances - metabolism Macromolecules Mathematical models Medical research Medicine Models, Biological Models, Theoretical Nanoparticles Neoplasms - metabolism Ordinary differential equations Permeability Scale (ratio) Small scale Spatial discrimination Spatial distribution Time response Tissue Distribution Tissues Tumor cells Tumor Microenvironment Tumors Ultrasonic imaging
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!