Dissecting the dynamics of HIV-1 protein sequence diversity

The rapid mutation of human immunodeficiency virus-type 1 (HIV-1) and the limited characterization of the composition and incidence of the variant population are major obstacles to the development of an effective HIV-1 vaccine. This issue was addressed by a comprehensive analysis of over 58,000 clad...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e59994-e59994
Hauptverfasser:	Hu, Yongli, Tan, Paul ThiamJoo, Tan, Tin Wee, August, J Thomas, Khan, Asif M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS vaccines Amino Acid Motifs Amino Acid Sequence Analysis Antigens Biochemistry Biology Computer Science Cytotoxicity Databases, Genetic env Gene Products, Human Immunodeficiency Virus - chemistry env Gene Products, Human Immunodeficiency Virus - genetics gag Gene Products, Human Immunodeficiency Virus - chemistry gag Gene Products, Human Immunodeficiency Virus - genetics Gag protein Genetic aspects Genetic Variation Histocompatibility antigen HLA HIV HIV-1 - classification HIV-1 - genetics Human immunodeficiency virus Humans Immunology Incidence Leukocytes Ligands Lymphocytes Lymphocytes T Medicine Molecular Sequence Data Mutation Nef protein Peptides Pharmacology Phylogenetics Physiological aspects Proteins Proteome Proteomes Receptors Sequence Alignment T cell receptors Taxonomy University graduates Vaccines Viral proteins Viral Proteins - chemistry Viral Proteins - genetics Virology Viruses
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