DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates

Biochemical and genetic studies suggest that vertebrates remove double-strand breaks (DSBs) from their genomes predominantly by two non-homologous end joining (NHEJ) pathways. While canonical NHEJ depends on the well characterized activities of DNA-dependent protein kinase (DNA-PK) and LIG4/XRCC4/XL...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59505-e59505
Hauptverfasser:	Paul, Katja, Wang, Minli, Mladenov, Emil, Bencsik-Theilen, Alena, Bednar, Theresa, Wu, Wenqi, Arakawa, Hiroshi, Iliakis, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Cell cycle Cell Line Cellular biology Chickens Deoxyribonucleic acid DNA DNA biosynthesis DNA Breaks, Double-Stranded DNA damage DNA End-Joining Repair DNA Ligase ATP DNA Ligases - deficiency DNA Ligases - genetics DNA Ligases - metabolism DNA-dependent protein kinase Down-Regulation Gene Knockdown Techniques Genetics Genomes Homology Kinases LIG4 protein Lymphocytes B Medical research Medical schools Mitochondria Mutation Non-homologous end joining Poly-ADP-Ribose Binding Proteins Saccharomyces cerevisiae Vertebrates Xenopus Proteins Yeast
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