Morphine induces albuminuria by compromising podocyte integrity

Morphine has been reported to accelerate the progression of chronic kidney disease. However, whether morphine affects slit diaphragm (SD), the major constituent of glomerular filtration barrier, is still unclear. In the present study, we examined the effect of morphine on glomerular filtration barri...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e55748
Hauptverfasser:	Lan, Xiqian, Rai, Partab, Chandel, Nirupama, Cheng, Kang, Lederman, Rivka, Saleem, Moin A, Mathieson, Peter W, Husain, Mohammad, Crosson, John T, Gupta, Kalpna, Malhotra, Ashwani, Singhal, Pravin C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - biosynthesis AKT protein Albuminuria - chemically induced Albuminuria - metabolism Albuminuria - pathology Animals Apoptosis Biology CD2-associated protein Cell Line, Transformed Cytoskeletal Proteins - biosynthesis Diabetes Diaphragm Disease Filtration Gene Expression Regulation - drug effects Glomerular Filtration Rate - drug effects Heroin Humans Hypertension Hypotheses In vivo methods and tests Integrity Intracellular Signaling Peptides and Proteins - biosynthesis JNK protein Kidneys Kinases MAP Kinase Kinase 4 - metabolism MAP Kinase Signaling System - drug effects Medical research Medical schools Medicine Membrane Proteins - biosynthesis Mice Morphine Morphine - adverse effects Morphine - pharmacology Narcotics Narcotics - adverse effects Narcotics - pharmacology Oxidative stress p38 Mitogen-Activated Protein Kinases - metabolism Pathology Podocytes - metabolism Podocytes - pathology Proteins Proto-Oncogene Proteins c-akt - metabolism Receptors Receptors, Opioid, kappa - biosynthesis Receptors, Opioid, mu - biosynthesis Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Rodents Urine
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