Decrease in blood pressure and regression of cardiovascular complications by angiotensin II vaccine in mice

Vaccines have been recently developed to treat various diseases such as cancer, rheumatoid arthritis and Alzheimer's disease in addition to infectious diseases. However, before use in the clinical setting, vaccines targeting self-antigens must be demonstrated to be effective and safe, evoking a...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e60493
Hauptverfasser:	Nakagami, Futoshi, Koriyama, Hiroshi, Nakagami, Hironori, Osako, Mariana Kiomy, Shimamura, Munehisa, Kyutoku, Mariko, Miyake, Takashi, Katsuya, Tomohiro, Rakugi, Hiromi, Morishita, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Angiotensin II - immunology Animals Antibodies, Neutralizing - pharmacology Antibody Formation - drug effects Antigens Aorta Arthritis Autoantigens Blood Blood pressure Blood Pressure - drug effects Calcification Cancer Cardiovascular Diseases - immunology Cardiovascular Diseases - physiopathology Cardiovascular Diseases - prevention & control Cell activation Cell growth Cell proliferation Child development Clinical trials Complications Disease Drug dosages Epigenetics Experiments Fibrosis Gene therapy Geriatrics Heart diseases Humans Hypertension Hypertension - chemically induced Hypertension - immunology Hypertension - physiopathology Hypertrophy Immune response Immune response (humoral) Immune system Immunization Immunology Infectious diseases Inflammation Kidney - drug effects Kidney - pathology Kidneys Lupus Lymphocyte Activation - drug effects Lymphocytes Lymphocytes B Lymphocytes T Male Medicine Mice Mice, Inbred C57BL Models, Cardiovascular Muscles Myocardium - pathology Peptides Proteins Rats Rats, Inbred SHR Rheumatoid arthritis Rodents Safety Side effects Signaling Smooth muscle T-Lymphocytes - drug effects T-Lymphocytes - immunology Vaccines Vaccines - immunology Ventricular Remodeling - drug effects
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