Endothelial NO synthase gene polymorphisms and risk of ischemic stroke in Asian population: a meta-analysis
The association between polymorphism 4b/a, T-786C and G894T in endothelial NO synthase gene (eNOS) and ischemic stroke (IS) remains controversial in Asian. A meta-analysis was performed to better clarify the association between eNOS gene and IS risk. Based on the search of PubMed, Web of Science (IS...
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| description | The association between polymorphism 4b/a, T-786C and G894T in endothelial NO synthase gene (eNOS) and ischemic stroke (IS) remains controversial in Asian. A meta-analysis was performed to better clarify the association between eNOS gene and IS risk.
Based on the search of PubMed, Web of Science (ISI), CNKI (National Knowledge Infrastructure), Wan Fang Med Online and CBM (Chinese Biology Medical Literature Database) databases, all eligible case-control or cohort studies were identified. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from fixed and random effect models were calculated. Heterogeneity among studies was evaluated using the I(2). Meta-regression was used to explore the potential sources of between-study heterogeneity. Begg's test was used to estimate publication bias.
Our study included 27 articles, contained 28 independent case-control studies, involved a total of 3,742 cases and 3,691 controls about 4b/a, 1,800 cases and 1,751 controls about T-786C and 2,747 cases and 2,872 controls about G894T. A significant association of 4a allele with increased risk of IS was found in dominant (FEM: OR = 1.498, 95% CI = 1.329-1.689), recessive (FEM: OR = 2.132, 95% CI = 1.383-3.286) and codominant (REM: OR = 1.456, 95% CI = 1.235-1.716) models. For T-786C and G894T, there were significant associations with dominant and codominant genetic models, but not with recessive genetic model.
The meta-analysis indicated that eNOS gene 4b/a, T-786C, G894T polymorphism might be associated with IS. |
| doi_str_mv | 10.1371/journal.pone.0060472 |
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Based on the search of PubMed, Web of Science (ISI), CNKI (National Knowledge Infrastructure), Wan Fang Med Online and CBM (Chinese Biology Medical Literature Database) databases, all eligible case-control or cohort studies were identified. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from fixed and random effect models were calculated. Heterogeneity among studies was evaluated using the I(2). Meta-regression was used to explore the potential sources of between-study heterogeneity. Begg's test was used to estimate publication bias.
Our study included 27 articles, contained 28 independent case-control studies, involved a total of 3,742 cases and 3,691 controls about 4b/a, 1,800 cases and 1,751 controls about T-786C and 2,747 cases and 2,872 controls about G894T. A significant association of 4a allele with increased risk of IS was found in dominant (FEM: OR = 1.498, 95% CI = 1.329-1.689), recessive (FEM: OR = 2.132, 95% CI = 1.383-3.286) and codominant (REM: OR = 1.456, 95% CI = 1.235-1.716) models. For T-786C and G894T, there were significant associations with dominant and codominant genetic models, but not with recessive genetic model.
The meta-analysis indicated that eNOS gene 4b/a, T-786C, G894T polymorphism might be associated with IS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0060472</identifier><identifier>PMID: 23544143</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Asian Continental Ancestry Group - genetics ; Biology ; Blood pressure ; Brain Ischemia - complications ; Brain Ischemia - genetics ; Case-Control Studies ; Confidence intervals ; Epidemiology ; Gene polymorphism ; Genetic analysis ; Genetic Heterogeneity ; Genetic Predisposition to Disease ; Health risks ; Heterogeneity ; Humans ; Ischemia ; Medical ethics ; Medicine ; Meta-analysis ; Nitric oxide ; Nitric Oxide Synthase Type III - genetics ; Nitric-oxide synthase ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Publication Bias ; Regression analysis ; Risk ; Risk Factors ; Rodents ; Statistical analysis ; Stroke ; Stroke - complications ; Stroke - genetics</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e60472-e60472</ispartof><rights>2013 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Wang et al 2013 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-5f4fbd20653062dea2e72322652fd040f695d26ea4804fc30e4ffcfba9f6b18a3</citedby><cites>FETCH-LOGICAL-c526t-5f4fbd20653062dea2e72322652fd040f695d26ea4804fc30e4ffcfba9f6b18a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609746/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609746/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23544143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Meiyun</creatorcontrib><creatorcontrib>Jiang, Xiubo</creatorcontrib><creatorcontrib>Wu, Wenlong</creatorcontrib><creatorcontrib>Zhang, Dongfeng</creatorcontrib><title>Endothelial NO synthase gene polymorphisms and risk of ischemic stroke in Asian population: a meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The association between polymorphism 4b/a, T-786C and G894T in endothelial NO synthase gene (eNOS) and ischemic stroke (IS) remains controversial in Asian. A meta-analysis was performed to better clarify the association between eNOS gene and IS risk.
Based on the search of PubMed, Web of Science (ISI), CNKI (National Knowledge Infrastructure), Wan Fang Med Online and CBM (Chinese Biology Medical Literature Database) databases, all eligible case-control or cohort studies were identified. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from fixed and random effect models were calculated. Heterogeneity among studies was evaluated using the I(2). Meta-regression was used to explore the potential sources of between-study heterogeneity. Begg's test was used to estimate publication bias.
Our study included 27 articles, contained 28 independent case-control studies, involved a total of 3,742 cases and 3,691 controls about 4b/a, 1,800 cases and 1,751 controls about T-786C and 2,747 cases and 2,872 controls about G894T. A significant association of 4a allele with increased risk of IS was found in dominant (FEM: OR = 1.498, 95% CI = 1.329-1.689), recessive (FEM: OR = 2.132, 95% CI = 1.383-3.286) and codominant (REM: OR = 1.456, 95% CI = 1.235-1.716) models. For T-786C and G894T, there were significant associations with dominant and codominant genetic models, but not with recessive genetic model.
The meta-analysis indicated that eNOS gene 4b/a, T-786C, G894T polymorphism might be associated with IS.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biology</subject><subject>Blood pressure</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - genetics</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Epidemiology</subject><subject>Gene polymorphism</subject><subject>Genetic analysis</subject><subject>Genetic Heterogeneity</subject><subject>Genetic Predisposition to Disease</subject><subject>Health risks</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Medical ethics</subject><subject>Medicine</subject><subject>Meta-analysis</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Nitric-oxide synthase</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Publication Bias</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Stroke - complications</subject><subject>Stroke - genetics</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIfsA_QGCJSy-7OP5KwgGpqgpUqugFztYkHm-869jBziLtvyfb3VYt4jTW-L03b0avKN6VdFnyqvy0jtsUwC_HGHBJqaKiYi-K07LhbKEY5S-fvE-Ks5zXlEpeK_W6OGFcClEKflpsroOJU4_egSc_7kjehamHjGSFAckY_W6IaexdHjKBYEhyeUOiJS53PQ6uI3lKcYPEBXKZHYSZMm49TC6GzwTIgBMsYLa5yy6_KV5Z8BnfHut58evr9c-r74vbu283V5e3i04yNS2kFbY1jCrJqWIGgWHFOGNKMmuooFY10jCFIGoqbMcpCms720JjVVvWwM-LDwfd0cesj3fKuuSc1k3T1PWMuDkgTIS1HpMbIO10BKfvGzGtNKTJdR41SqitbCpLmRENlcCVtU0pjWmZqlU1a305Ttu2A5oOw5TAPxN9_hNcr1fxj-aKNpVQs8DFUSDF31vMkx7m66L3EDBu974ZqziT97M-_gP9_3bigOpSzDmhfTRTUr3PzgNL77Ojj9mZae-fLvJIeggL_wv1xcPD</recordid><startdate>20130327</startdate><enddate>20130327</enddate><creator>Wang, Meiyun</creator><creator>Jiang, Xiubo</creator><creator>Wu, Wenlong</creator><creator>Zhang, Dongfeng</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130327</creationdate><title>Endothelial NO synthase gene polymorphisms and risk of ischemic stroke in Asian population: a meta-analysis</title><author>Wang, Meiyun ; Jiang, Xiubo ; Wu, Wenlong ; Zhang, Dongfeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-5f4fbd20653062dea2e72322652fd040f695d26ea4804fc30e4ffcfba9f6b18a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Asian Continental Ancestry Group - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Meiyun</au><au>Jiang, Xiubo</au><au>Wu, Wenlong</au><au>Zhang, Dongfeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial NO synthase gene polymorphisms and risk of ischemic stroke in Asian population: a meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-03-27</date><risdate>2013</risdate><volume>8</volume><issue>3</issue><spage>e60472</spage><epage>e60472</epage><pages>e60472-e60472</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The association between polymorphism 4b/a, T-786C and G894T in endothelial NO synthase gene (eNOS) and ischemic stroke (IS) remains controversial in Asian. A meta-analysis was performed to better clarify the association between eNOS gene and IS risk.
Based on the search of PubMed, Web of Science (ISI), CNKI (National Knowledge Infrastructure), Wan Fang Med Online and CBM (Chinese Biology Medical Literature Database) databases, all eligible case-control or cohort studies were identified. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from fixed and random effect models were calculated. Heterogeneity among studies was evaluated using the I(2). Meta-regression was used to explore the potential sources of between-study heterogeneity. Begg's test was used to estimate publication bias.
Our study included 27 articles, contained 28 independent case-control studies, involved a total of 3,742 cases and 3,691 controls about 4b/a, 1,800 cases and 1,751 controls about T-786C and 2,747 cases and 2,872 controls about G894T. A significant association of 4a allele with increased risk of IS was found in dominant (FEM: OR = 1.498, 95% CI = 1.329-1.689), recessive (FEM: OR = 2.132, 95% CI = 1.383-3.286) and codominant (REM: OR = 1.456, 95% CI = 1.235-1.716) models. For T-786C and G894T, there were significant associations with dominant and codominant genetic models, but not with recessive genetic model.
The meta-analysis indicated that eNOS gene 4b/a, T-786C, G894T polymorphism might be associated with IS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23544143</pmid><doi>10.1371/journal.pone.0060472</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Asian Continental Ancestry Group - genetics Biology Blood pressure Brain Ischemia - complications Brain Ischemia - genetics Case-Control Studies Confidence intervals Epidemiology Gene polymorphism Genetic analysis Genetic Heterogeneity Genetic Predisposition to Disease Health risks Heterogeneity Humans Ischemia Medical ethics Medicine Meta-analysis Nitric oxide Nitric Oxide Synthase Type III - genetics Nitric-oxide synthase Polymorphism Polymorphism, Single Nucleotide - genetics Publication Bias Regression analysis Risk Risk Factors Rodents Statistical analysis Stroke Stroke - complications Stroke - genetics |
| title | Endothelial NO synthase gene polymorphisms and risk of ischemic stroke in Asian population: a meta-analysis |
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