Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse

Our ability to successfully intervene in disease processes is dependent on definitive diagnosis. In the case of autoimmune disease, this is particularly challenging because progression of disease is lengthy and multifactorial. Here we show the first chronological compendium of transcriptional and ce...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59701-e59701
Hauptverfasser:	Carrero, Javier A, Calderon, Boris, Towfic, Fadi, Artyomov, Maxim N, Unanue, Emil R
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Autoimmune diseases Biology Cell activation Cell Cycle Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Disease Progression Experiments Female Flow cytometry Gene expression Genomes Homeodomain Proteins - metabolism Immunology Infiltration Interferon Interferon Type I - metabolism Islets of Langerhans Islets of Langerhans - immunology Lymphocyte Activation Lymphocytes Lymphocytes T Medicine Mice Mice, Inbred NOD Myeloid Cells - immunology NF-κB protein Pancreas Pathology Protein Interaction Maps Rodents Signatures Species Specificity T-Lymphocytes - immunology Time Factors Transcription Transcription factors Transcription, Genetic Transgenic animals
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