Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis

Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; levels of S1P in the tissues are controlled by S1P lyase (Sgpl1). Hence, Sgpl1 offers a target to block T cell-dependent inflammatory processes. However, the involvement of Sgpl1 in models of disease has not been ful...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59630-e59630
Hauptverfasser:	Billich, Andreas, Baumruker, Thomas, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Calzascia, Thomas, Isken, Andrea, Kinzel, Bernd, Loetscher, Erika, Metzler, Barbara, Mueller, Matthias, Nuesslein-Hildesheim, Barbara, Kleylein-Sohn, Bernadette
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde-Lyases - deficiency Aldehyde-Lyases - metabolism Animal models Animal tissues Animals Biology Biomedical research Brain Brain - metabolism CD4-Positive T-Lymphocytes - immunology Central nervous system Egress Encephalomyelitis, Autoimmune, Experimental - blood Encephalomyelitis, Autoimmune, Experimental - complications Encephalomyelitis, Autoimmune, Experimental - enzymology Encephalomyelitis, Autoimmune, Experimental - prevention & control Enzymes Experimental allergic encephalomyelitis Forkhead Transcription Factors - metabolism Gene expression Hypersensitivity, Delayed - blood Hypersensitivity, Delayed - complications Hypersensitivity, Delayed - immunology Hypersensitivity, Delayed - pathology Immigration Immunologic Memory - immunology Immunological memory Immunoregulation Inflammation Integrases - metabolism Kinases Lipids Lymph nodes Lymph Nodes - immunology Lymph Nodes - pathology Lymphocyte Count Lymphocytes Lymphocytes T Medicine Memory cells Mice Mice, Knockout Multiple sclerosis Organs Phosphates Reduction Rodents Sheep Sphingolipids - metabolism Sphingosine 1-phosphate Spleen Spleen - immunology Spleen - pathology Stem cells Survival Analysis Therapeutic applications Thymus Thymus Gland - immunology Thymus Gland - pathology
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