Association between virulence and triazole tolerance in the phytopathogenic fungus Mycosphaerella graminicola
Host resistance and synthetic antimicrobials such as fungicides are two of the main approaches used to control plant diseases in conventional agriculture. Although pathogens often evolve to overcome host resistance and antimicrobials, the majority of reports have involved qualitative host - pathogen...
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| Veröffentlicht in: | PloS one 2013-03, Vol.8 (3), p.e59568 |
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| creator | Yang, Lina Gao, Fangluan Shang, Liping Zhan, Jiasui McDonald, Bruce A |
| description | Host resistance and synthetic antimicrobials such as fungicides are two of the main approaches used to control plant diseases in conventional agriculture. Although pathogens often evolve to overcome host resistance and antimicrobials, the majority of reports have involved qualitative host - pathogen interactions or antimicrobials targeting a single pathogen protein or metabolic pathway. Studies that consider jointly the evolution of virulence, defined as the degree of damage caused to a host by parasite infection, and antimicrobial resistance are rare. Here we compared virulence and fungicide tolerance in the fungal pathogen Mycosphaerella graminicola sampled from wheat fields across three continents and found a positive correlation between virulence and tolerance to a triazole fungicide. We also found that quantitative host resistance selected for higher pathogen virulence. The possible mechanisms responsible for these observations and their consequences for sustainable disease management are discussed. |
| doi_str_mv | 10.1371/journal.pone.0059568 |
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Although pathogens often evolve to overcome host resistance and antimicrobials, the majority of reports have involved qualitative host - pathogen interactions or antimicrobials targeting a single pathogen protein or metabolic pathway. Studies that consider jointly the evolution of virulence, defined as the degree of damage caused to a host by parasite infection, and antimicrobial resistance are rare. Here we compared virulence and fungicide tolerance in the fungal pathogen Mycosphaerella graminicola sampled from wheat fields across three continents and found a positive correlation between virulence and tolerance to a triazole fungicide. We also found that quantitative host resistance selected for higher pathogen virulence. The possible mechanisms responsible for these observations and their consequences for sustainable disease management are discussed.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0059568</identifier><identifier>PMID: 23555044</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Agricultural management ; Agriculture ; Antimicrobial agents ; Antimicrobial resistance ; Ascomycota - drug effects ; Ascomycota - pathogenicity ; Biology ; Biosynthesis ; Continents ; Disease control ; Drug resistance ; Drug Resistance, Fungal ; Epidemics ; Evolution ; Fungi ; Fungicides ; Fungicides, Industrial - pharmacology ; Health aspects ; Host plants ; Infections ; Kinases ; Laboratories ; Medicine ; Metabolites ; Microbial drug resistance ; Mutation ; Mycosphaerella graminicola ; Parasitic diseases ; Pathogens ; Pesticides ; Phytopathogenic fungi ; Plant diseases ; Plant Leaves - microbiology ; Plants - microbiology ; Proteins ; Studies ; Triazoles ; Triazoles - pharmacology ; Virology ; Virulence ; Virulence (Microbiology) ; Wheat</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e59568</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Yang et al. 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| subjects | Agricultural management Agriculture Antimicrobial agents Antimicrobial resistance Ascomycota - drug effects Ascomycota - pathogenicity Biology Biosynthesis Continents Disease control Drug resistance Drug Resistance, Fungal Epidemics Evolution Fungi Fungicides Fungicides, Industrial - pharmacology Health aspects Host plants Infections Kinases Laboratories Medicine Metabolites Microbial drug resistance Mutation Mycosphaerella graminicola Parasitic diseases Pathogens Pesticides Phytopathogenic fungi Plant diseases Plant Leaves - microbiology Plants - microbiology Proteins Studies Triazoles Triazoles - pharmacology Virology Virulence Virulence (Microbiology) Wheat |
| title | Association between virulence and triazole tolerance in the phytopathogenic fungus Mycosphaerella graminicola |
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