Next-generation site-directed transgenesis in the malaria vector mosquito Anopheles gambiae: self-docking strains expressing germline-specific phiC31 integrase

Diseases transmitted by mosquitoes have a devastating impact on global health and the situation is complicated due to difficulties with both existing control measures and the impact of climate change. Genetically modified mosquitoes that are refractory to disease transmission are seen as having grea...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59264
Hauptverfasser:	Meredith, Janet M, Underhill, Ann, McArthur, Clare C, Eggleston, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes aegypti Animals Anopheles Anopheles - genetics Anopheles gambiae Anopheles stephensi Aquatic insects Biology Ceratitis capitata Climate change Comparative studies Culicidae Disease transmission Docking Drosophila melanogaster Efficiency Environmental impact Experiments Fitness Gene expression Genes Genetic engineering Genetic modification Genetic transformation Genetically modified organisms Genomes Germ-Line Mutation - genetics Global health Insect Vectors - genetics Insects Integrase Integrases - genetics Integration Life sciences Malaria Malaria - transmission Medicine Mosquitoes Mutagenesis, Site-Directed Parasites Parasitology Phages Plasmodium Regulatory sequences Reproductive fitness Streptomyces Studies Technology Transformation Transgenes Transposons Tropical diseases Vector-borne diseases
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