Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress

The intraerythrocytic malaria parasite is susceptible to oxidative stress and this may play a role in the mechanism of action of some antimalarial agents. Here we show that exposure of the intraerythrocytic malaria parasite to the oxidising agent hydrogen peroxide results in a fall in the intracellu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e58933
Hauptverfasser:	van Schalkwyk, Donelly A, Saliba, Kevin J, Biagini, Giancarlo A, Bray, Patrick G, Kirk, Kiaran
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphate - metabolism Antimalarial agents Biology Cytosol Cytosol - drug effects Cytosol - metabolism Erythrocytes Experiments H+-transporting ATPase Hydrogen Hydrogen peroxide Hydrogen Peroxide - pharmacology Hydrogen-Ion Concentration Inorganic pyrophosphatase Inorganic Pyrophosphatase - metabolism Intracellular Membranes - drug effects Intracellular Membranes - metabolism Light effects Lipid peroxidation Lysis Malaria Oxidative Stress Parasites Peroxides pH control pH effects Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - metabolism Pyrophosphatase Saccharomyces cerevisiae Studies Tropical diseases Vacuolar Proton-Translocating ATPases - antagonists & inhibitors Vacuoles - drug effects Vacuoles - metabolism Vector-borne diseases Yeast
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!