Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice

Changes in the expression of γ-aminobutyric acid type A (GABAA) receptors can either drive or mediate homeostatic alterations in neuronal excitability. A homeostatic relationship between α5 subunit-containing GABAA (α5GABAA) receptors that generate a tonic inhibitory conductance, and HCN channels th...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e58679-e58679
Hauptverfasser:	Bonin, Robert P, Zurek, Agnieszka A, Yu, Jieying, Bayliss, Douglas A, Orser, Beverley A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Anion channels Biology Brain Cations Channels Conductance Cyclic Nucleotide-Gated Cation Channels - metabolism Electric Impedance Electrophysiological Phenomena Embryos Excitability GABA Hippocampus Hippocampus - cytology Homeostasis Hyperpolarization Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Ion channels (cyclic nucleotide-gated) Membrane potential Membrane Potentials Mice Neurons Neurons - cytology Neurons - metabolism Physiology Potassium Channels - metabolism Preservation Pyramidal cells Receptor mechanisms Receptors Receptors, GABA-A - deficiency Reduction Resistance Rodents Up-Regulation γ-Aminobutyric acid A receptors
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