Postoperative neutrophil-to-lymphocyte ratio change predicts survival of patients with small hepatocellular carcinoma undergoing radiofrequency ablation
An elevated preoperative neutrophil-to-lymphocyte ratio (NLR) has been reported to be a prognostic factor for hepatocellular carcinoma (HCC) patients after treatment. However, the clinical implication of postoperative NLR change remains unclear. From May 2005 to Aug 2008, a cohort of consecutive 178...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-03, Vol.8 (3), p.e58184 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | e58184 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Dan, Jiaqiang Zhang, Yaojun Peng, Zhenwei Huang, Junting Gao, Hengjun Xu, Li Chen, Minshan |
| description | An elevated preoperative neutrophil-to-lymphocyte ratio (NLR) has been reported to be a prognostic factor for hepatocellular carcinoma (HCC) patients after treatment. However, the clinical implication of postoperative NLR change remains unclear.
From May 2005 to Aug 2008, a cohort of consecutive 178 small HCC patients treated with radiofrequency ablation (RFA) was retrospectively reviewed. The NLR was recorded within 3 days before and 1 month after RFA. Baseline characteristics, overall survival (OS) and recurrence free survival (RFS) were compared according to preoperative NLR and/or postoperative NLR change. Prognostic factors were assessed by multivariate analysis.
Compared with preoperative NLR level, postoperative NLR decreased in 87 patients and increased in 91 patients after RFA. No significant differences were identified between two groups in commonly used clinic-pathologic features. The 1, 3, 5 years OS was 98.8%, 78.6%, 67.1% for NLR decreased group, and 92.2%, 55.5%, 35.4% for NLR increased group respectively (P |
| doi_str_mv | 10.1371/journal.pone.0058184 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1330895298</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478277295</galeid><doaj_id>oai_doaj_org_article_1195096dfa884b24bd5a54fbcacdeb4c</doaj_id><sourcerecordid>A478277295</sourcerecordid><originalsourceid>FETCH-LOGICAL-c659t-4b2e3193db05f755565e8b1f3aee6bdfb233c635b90160de6471ae5f2f8154c33</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7jr6D0QLguBFx6Zp0vZGWBY_BhZW_LoNaXLSZkmbmqSj80_8uWac7jIDCpKLhJPnvOfkJSdJnqJ8jXCFXt_Y2Y3crCc7wjrPSY3q8l5yjhpcZLTI8f2j81nyyPubCOGa0ofJWYEJomVZnSe_Plof7ASOB72FdIQ5ODv12mTBZmY3TL0VuwDp_t6moudjB-nkQGoRfOpnt9VbblKr0ikSMMbgDx361A_cmLSHGLUCjJkNd6ngTujRDjydRwmus3rsorLUVjn4PsModilvzb7U-Dh5oLjx8GTZV8nXd2-_XH7Irq7fby4vrjJBSROysi0Ax3fKNieqIoRQAnWLFOYAtJWqLTAWFJO2yRHNJdCyQhyIKlSNSCkwXiXPD7qTsZ4tpnqGMM7rhhRNHYnNgZCW37DJ6YG7HbNcsz8B6zrGXdDCAEOoIXlDpeJ1HTsrW0k4KVUruJDQxnKr5M1SbW4HkCIa5rg5ET29GXXPOrtlmDQVxXkUeLEIOBsd8-EfLS9Ux2NXelQ2iolBe8EuyqouqqpoSKTWf6HikjBoEb-V0jF-kvDqJCEyAX6Gjs_es83nT__PXn87ZV8esT1wE3pvzbz_B_4ULA-gcNZ7B-rOOZSz_VTcusH2U8GWqYhpz45dv0u6HQP8G8j0DeQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1330895298</pqid></control><display><type>article</type><title>Postoperative neutrophil-to-lymphocyte ratio change predicts survival of patients with small hepatocellular carcinoma undergoing radiofrequency ablation</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Dan, Jiaqiang ; Zhang, Yaojun ; Peng, Zhenwei ; Huang, Junting ; Gao, Hengjun ; Xu, Li ; Chen, Minshan</creator><creatorcontrib>Dan, Jiaqiang ; Zhang, Yaojun ; Peng, Zhenwei ; Huang, Junting ; Gao, Hengjun ; Xu, Li ; Chen, Minshan</creatorcontrib><description>An elevated preoperative neutrophil-to-lymphocyte ratio (NLR) has been reported to be a prognostic factor for hepatocellular carcinoma (HCC) patients after treatment. However, the clinical implication of postoperative NLR change remains unclear.
From May 2005 to Aug 2008, a cohort of consecutive 178 small HCC patients treated with radiofrequency ablation (RFA) was retrospectively reviewed. The NLR was recorded within 3 days before and 1 month after RFA. Baseline characteristics, overall survival (OS) and recurrence free survival (RFS) were compared according to preoperative NLR and/or postoperative NLR change. Prognostic factors were assessed by multivariate analysis.
Compared with preoperative NLR level, postoperative NLR decreased in 87 patients and increased in 91 patients after RFA. No significant differences were identified between two groups in commonly used clinic-pathologic features. The 1, 3, 5 years OS was 98.8%, 78.6%, 67.1% for NLR decreased group, and 92.2%, 55.5%, 35.4% for NLR increased group respectively (P<0.001); the corresponding RFS was 94.2%, 65.2%, 33.8% and 81.7%, 46.1%, 12.4% respectively (P<0.001). In subgroup analysis, the survival of patients with lower or higher preoperative NLR can be distinguished more accurate by postoperative NLR change. Multivariate analysis showed that postoperative NLR change, but not preoperative NLR, was an independent prognostic factor for both OS (P<0.001, HR = 2.39, 95%CI 1.53-3.72) and RFS (P = 0.003, HR = 1.69, 95%CI 1.87-8.24).
The postoperative NLR change was an independent prognostic factor for small HCC patient undergoing RFA, and patients with decreased NLR indicated better survival than those with increased NLR.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0058184</identifier><identifier>PMID: 23516447</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Ablation ; Ablation (Surgery) ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Biology ; Cancer therapies ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - surgery ; Catheter Ablation ; Cell survival ; Chemotherapy ; Colorectal cancer ; Female ; Gastric cancer ; Hepatocellular carcinoma ; Humans ; Laboratories ; Leukocyte Count ; Liver cancer ; Liver Neoplasms - blood ; Liver Neoplasms - mortality ; Liver Neoplasms - surgery ; Lymphocytes ; Male ; Medical prognosis ; Medical research ; Medicine ; Metastasis ; Middle Aged ; Mortality ; Multivariate analysis ; Neutrophils ; Oncology ; Patient outcomes ; Patients ; Postoperative Period ; Prognosis ; Radio frequency ; Radiofrequency ablation ; Retrospective Studies ; Stomach cancer ; Surgery ; Surgical outcomes ; Survival</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e58184</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Dan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Dan et al 2013 Dan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-4b2e3193db05f755565e8b1f3aee6bdfb233c635b90160de6471ae5f2f8154c33</citedby><cites>FETCH-LOGICAL-c659t-4b2e3193db05f755565e8b1f3aee6bdfb233c635b90160de6471ae5f2f8154c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597630/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597630/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23516447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dan, Jiaqiang</creatorcontrib><creatorcontrib>Zhang, Yaojun</creatorcontrib><creatorcontrib>Peng, Zhenwei</creatorcontrib><creatorcontrib>Huang, Junting</creatorcontrib><creatorcontrib>Gao, Hengjun</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><creatorcontrib>Chen, Minshan</creatorcontrib><title>Postoperative neutrophil-to-lymphocyte ratio change predicts survival of patients with small hepatocellular carcinoma undergoing radiofrequency ablation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>An elevated preoperative neutrophil-to-lymphocyte ratio (NLR) has been reported to be a prognostic factor for hepatocellular carcinoma (HCC) patients after treatment. However, the clinical implication of postoperative NLR change remains unclear.
From May 2005 to Aug 2008, a cohort of consecutive 178 small HCC patients treated with radiofrequency ablation (RFA) was retrospectively reviewed. The NLR was recorded within 3 days before and 1 month after RFA. Baseline characteristics, overall survival (OS) and recurrence free survival (RFS) were compared according to preoperative NLR and/or postoperative NLR change. Prognostic factors were assessed by multivariate analysis.
Compared with preoperative NLR level, postoperative NLR decreased in 87 patients and increased in 91 patients after RFA. No significant differences were identified between two groups in commonly used clinic-pathologic features. The 1, 3, 5 years OS was 98.8%, 78.6%, 67.1% for NLR decreased group, and 92.2%, 55.5%, 35.4% for NLR increased group respectively (P<0.001); the corresponding RFS was 94.2%, 65.2%, 33.8% and 81.7%, 46.1%, 12.4% respectively (P<0.001). In subgroup analysis, the survival of patients with lower or higher preoperative NLR can be distinguished more accurate by postoperative NLR change. Multivariate analysis showed that postoperative NLR change, but not preoperative NLR, was an independent prognostic factor for both OS (P<0.001, HR = 2.39, 95%CI 1.53-3.72) and RFS (P = 0.003, HR = 1.69, 95%CI 1.87-8.24).
The postoperative NLR change was an independent prognostic factor for small HCC patient undergoing RFA, and patients with decreased NLR indicated better survival than those with increased NLR.</description><subject>Ablation</subject><subject>Ablation (Surgery)</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biology</subject><subject>Cancer therapies</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Catheter Ablation</subject><subject>Cell survival</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Leukocyte Count</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - surgery</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Neutrophils</subject><subject>Oncology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Radio frequency</subject><subject>Radiofrequency ablation</subject><subject>Retrospective Studies</subject><subject>Stomach cancer</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Survival</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7jr6D0QLguBFx6Zp0vZGWBY_BhZW_LoNaXLSZkmbmqSj80_8uWac7jIDCpKLhJPnvOfkJSdJnqJ8jXCFXt_Y2Y3crCc7wjrPSY3q8l5yjhpcZLTI8f2j81nyyPubCOGa0ofJWYEJomVZnSe_Plof7ASOB72FdIQ5ODv12mTBZmY3TL0VuwDp_t6moudjB-nkQGoRfOpnt9VbblKr0ikSMMbgDx361A_cmLSHGLUCjJkNd6ngTujRDjydRwmus3rsorLUVjn4PsModilvzb7U-Dh5oLjx8GTZV8nXd2-_XH7Irq7fby4vrjJBSROysi0Ax3fKNieqIoRQAnWLFOYAtJWqLTAWFJO2yRHNJdCyQhyIKlSNSCkwXiXPD7qTsZ4tpnqGMM7rhhRNHYnNgZCW37DJ6YG7HbNcsz8B6zrGXdDCAEOoIXlDpeJ1HTsrW0k4KVUruJDQxnKr5M1SbW4HkCIa5rg5ET29GXXPOrtlmDQVxXkUeLEIOBsd8-EfLS9Ux2NXelQ2iolBe8EuyqouqqpoSKTWf6HikjBoEb-V0jF-kvDqJCEyAX6Gjs_es83nT__PXn87ZV8esT1wE3pvzbz_B_4ULA-gcNZ7B-rOOZSz_VTcusH2U8GWqYhpz45dv0u6HQP8G8j0DeQ</recordid><startdate>20130314</startdate><enddate>20130314</enddate><creator>Dan, Jiaqiang</creator><creator>Zhang, Yaojun</creator><creator>Peng, Zhenwei</creator><creator>Huang, Junting</creator><creator>Gao, Hengjun</creator><creator>Xu, Li</creator><creator>Chen, Minshan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130314</creationdate><title>Postoperative neutrophil-to-lymphocyte ratio change predicts survival of patients with small hepatocellular carcinoma undergoing radiofrequency ablation</title><author>Dan, Jiaqiang ; Zhang, Yaojun ; Peng, Zhenwei ; Huang, Junting ; Gao, Hengjun ; Xu, Li ; Chen, Minshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-4b2e3193db05f755565e8b1f3aee6bdfb233c635b90160de6471ae5f2f8154c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Ablation</topic><topic>Ablation (Surgery)</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biology</topic><topic>Cancer therapies</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Catheter Ablation</topic><topic>Cell survival</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Leukocyte Count</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - surgery</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Neutrophils</topic><topic>Oncology</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Radio frequency</topic><topic>Radiofrequency ablation</topic><topic>Retrospective Studies</topic><topic>Stomach cancer</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dan, Jiaqiang</creatorcontrib><creatorcontrib>Zhang, Yaojun</creatorcontrib><creatorcontrib>Peng, Zhenwei</creatorcontrib><creatorcontrib>Huang, Junting</creatorcontrib><creatorcontrib>Gao, Hengjun</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><creatorcontrib>Chen, Minshan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dan, Jiaqiang</au><au>Zhang, Yaojun</au><au>Peng, Zhenwei</au><au>Huang, Junting</au><au>Gao, Hengjun</au><au>Xu, Li</au><au>Chen, Minshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative neutrophil-to-lymphocyte ratio change predicts survival of patients with small hepatocellular carcinoma undergoing radiofrequency ablation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-03-14</date><risdate>2013</risdate><volume>8</volume><issue>3</issue><spage>e58184</spage><pages>e58184-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>An elevated preoperative neutrophil-to-lymphocyte ratio (NLR) has been reported to be a prognostic factor for hepatocellular carcinoma (HCC) patients after treatment. However, the clinical implication of postoperative NLR change remains unclear.
From May 2005 to Aug 2008, a cohort of consecutive 178 small HCC patients treated with radiofrequency ablation (RFA) was retrospectively reviewed. The NLR was recorded within 3 days before and 1 month after RFA. Baseline characteristics, overall survival (OS) and recurrence free survival (RFS) were compared according to preoperative NLR and/or postoperative NLR change. Prognostic factors were assessed by multivariate analysis.
Compared with preoperative NLR level, postoperative NLR decreased in 87 patients and increased in 91 patients after RFA. No significant differences were identified between two groups in commonly used clinic-pathologic features. The 1, 3, 5 years OS was 98.8%, 78.6%, 67.1% for NLR decreased group, and 92.2%, 55.5%, 35.4% for NLR increased group respectively (P<0.001); the corresponding RFS was 94.2%, 65.2%, 33.8% and 81.7%, 46.1%, 12.4% respectively (P<0.001). In subgroup analysis, the survival of patients with lower or higher preoperative NLR can be distinguished more accurate by postoperative NLR change. Multivariate analysis showed that postoperative NLR change, but not preoperative NLR, was an independent prognostic factor for both OS (P<0.001, HR = 2.39, 95%CI 1.53-3.72) and RFS (P = 0.003, HR = 1.69, 95%CI 1.87-8.24).
The postoperative NLR change was an independent prognostic factor for small HCC patient undergoing RFA, and patients with decreased NLR indicated better survival than those with increased NLR.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23516447</pmid><doi>10.1371/journal.pone.0058184</doi><tpages>e58184</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-03, Vol.8 (3), p.e58184 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1330895298 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Ablation Ablation (Surgery) Adult Aged Aged, 80 and over Analysis Biology Cancer therapies Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - surgery Catheter Ablation Cell survival Chemotherapy Colorectal cancer Female Gastric cancer Hepatocellular carcinoma Humans Laboratories Leukocyte Count Liver cancer Liver Neoplasms - blood Liver Neoplasms - mortality Liver Neoplasms - surgery Lymphocytes Male Medical prognosis Medical research Medicine Metastasis Middle Aged Mortality Multivariate analysis Neutrophils Oncology Patient outcomes Patients Postoperative Period Prognosis Radio frequency Radiofrequency ablation Retrospective Studies Stomach cancer Surgery Surgical outcomes Survival |
| title | Postoperative neutrophil-to-lymphocyte ratio change predicts survival of patients with small hepatocellular carcinoma undergoing radiofrequency ablation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T09%3A22%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Postoperative%20neutrophil-to-lymphocyte%20ratio%20change%20predicts%20survival%20of%20patients%20with%20small%20hepatocellular%20carcinoma%20undergoing%20radiofrequency%20ablation&rft.jtitle=PloS%20one&rft.au=Dan,%20Jiaqiang&rft.date=2013-03-14&rft.volume=8&rft.issue=3&rft.spage=e58184&rft.pages=e58184-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0058184&rft_dat=%3Cgale_plos_%3EA478277295%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1330895298&rft_id=info:pmid/23516447&rft_galeid=A478277295&rft_doaj_id=oai_doaj_org_article_1195096dfa884b24bd5a54fbcacdeb4c&rfr_iscdi=true |