Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina

Adeno-associated viral vectors (AAV) have been shown to be safe in the treatment of retinal degenerations in clinical trials. Thus, improving the efficiency of viral gene delivery has become increasingly important to increase the success of clinical trials. In this study, structural domains of diffe...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e60361-e60361
Hauptverfasser:	Charbel Issa, Peter, De Silva, Samantha R, Lipinski, Daniel M, Singh, Mandeep S, Mouravlev, Alexandre, You, Qisheng, Barnard, Alun R, Hankins, Mark W, During, Matthew J, Maclaren, Robert E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animal tissues Animals Biology Biomedical research Brain Cell Line Clinical trials Degeneration Dependovirus - classification Dependovirus - physiology Drug dosages Efficiency Gene Expression Gene sequencing Gene therapy Gene transfer Gene Transfer Techniques Genetic Vectors - administration & dosage Genetic Vectors - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Hospitals Humans Immune response Immune response (cell-mediated) Laboratories Lymphocytes T Medical research Medicine Mice Mice, Transgenic Mutation Neurodegeneration Neurosciences Photoreceptors Primates Proteins Recombination, Genetic Retina Retina - metabolism Retina - virology Retinal degeneration Retinal Degeneration - genetics Retinal Degeneration - metabolism Rodents Serotypes Therapeutic applications Transduction, Genetic Tropism Vectors (Biology) Viral Tropism
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