Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-κB signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts

Porphyromonas gingivalis is a major pathogen of periodontal disease that affects a majority of adults worldwide. Increasing evidence shows that periodontal disease is linked to various systemic diseases like diabetes and cardiovascular disease, by contributing to increased systemic levels of inflamm...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e58496
Hauptverfasser:	Herath, Thanuja D K, Darveau, Richard P, Seneviratne, Chaminda J, Wang, Cun-Yu, Wang, Yu, Jin, Lijian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Adults Bacteria Biology Cardiovascular diseases Cell interactions CXCL10 protein Cytokines Cytokines - biosynthesis Cytokines - immunology Dentistry Diabetes mellitus E coli Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblasts Gene expression Genes Gingiva Gingiva - immunology Gingiva - metabolism Gingiva - microbiology Gingiva - pathology Gram-negative bacteria Granulocyte colony-stimulating factor Granulocyte-macrophage colony-stimulating factor Human behavior Humans Inflammation Inflammatory response Interleukin 6 Interleukin 8 Kinases Lipid A Lipid A - chemistry Lipid A - immunology Lipid A - pharmacology Lipids Lipopolysaccharides MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Medicine Monocyte chemoattractant protein 1 NF-kappa B - immunology NF-kappa B - metabolism NF-κB protein Pathogenesis Pathways Periodontal disease Periodontics Porphyromonas gingivalis Porphyromonas gingivalis - chemistry Porphyromonas gingivalis - immunology Receptors Rodents Signal transduction Signaling Studies Tissues TLR2 protein TLR4 protein Toll-Like Receptor 4 - immunology Toll-Like Receptor 4 - metabolism Toll-like receptors Transduction
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