Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules

Mitotic regulators exhibiting gain of function in tumor cells are considered useful cancer therapeutic targets for the development of small-molecule inhibitors. The human Aurora kinases are a family of such targets. In this study, from a panel of 105 potential small-molecule inhibitors, two compound...

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Veröffentlicht in:PloS one 2013-03, Vol.8 (3), p.e58485
Hauptverfasser: Kesisova, Iliana A, Nakos, Konstantinos C, Tsolou, Avgi, Angelis, Dimitrios, Lewis, Joe, Chatzaki, Aikaterini, Agianian, Bogos, Giannis, Athanassios, Koffa, Maria D
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Sprache:eng
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