Synergistic activation of innate and adaptive immune mechanisms in the treatment of gonadotropin-sensitive tumors

Human chorionic gonadotropin (hCG) prolongs the secretion of progesterone from the corpus luteum, providing a critical stimulus for the sustenance of pregnancy. hCG (or individual subunits) is also secreted by a variety of trophoblastic and non-trophoblastic cancers and has been associated with poor...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61288-e61288
Hauptverfasser:	Bose, Anjali, Huhtaniemi, Ilpo, Singh, Om, Pal, Rahul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Adjuvants, Immunologic - physiology Alum Aluminum sulfate Animals Antibodies Anticancer properties Antigen-presenting cells Antigen-Presenting Cells - immunology Antigen-Presenting Cells - microbiology Antigens Bacillus Biocompatibility Biology Bladder cancer Cancer Cancer Vaccines - immunology Cell Line, Tumor Cell Proliferation Chorionic gonadotropin Chorionic Gonadotropin - genetics Chorionic Gonadotropin - immunology Chorionic gonadotropins Corpus luteum Cytokines Cytotoxicity Dendritic cells Female Formulations Genetic diversity Genetic engineering Glycoproteins Gonadotropins Growth factors Humans Immunity Immunity, Innate Immunization Immunogenicity Immunoglobulins Immunology Immunomodulation Immunotherapy Inflammation Interleukin 12 Interleukin 6 Lung cancer Lymphocytes T Male Medical prognosis Medical research Medicine Mice Mycobacterium Mycobacterium - physiology Mycobacterium tuberculosis Pituitary (anterior) Pregnancy Progesterone Prognosis Rodents Sex hormones Surgical implants T cells Toxicity Transgenic animals Transgenic mice Tuberculosis Tumor cells Tumor necrosis factor-α Tumorigenesis Tumors Vaccination Vaccines γ-Interferon
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