G protein-coupled receptor 87 (GPR87) promotes the growth and metastasis of CD133⁺ cancer stem-like cells in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a prevalent disease worldwide, and the majority of HCC-related deaths occur due to local invasion and distant metastasis. Cancer stem cells (CSCs) are a small subpopulation of cancer cells that have been hypothesized to be responsible for metastatic disease. Recentl...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61056-e61056
Hauptverfasser:	Yan, Mingxia, Li, Hong, Zhu, Miaoxin, Zhao, Fangyu, Zhang, Lixing, Chen, Taoyang, Jiang, Guoping, Xie, Haiyang, Cui, Ying, Yao, Ming, Li, Jinjun
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Antigens, CD - immunology Base Sequence Biology Cancer Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Division - physiology Cell Line, Tumor Cloning DNA Primers Gene expression Glycoproteins - immunology Growth factors Hepatocellular carcinoma Hepatology Humans Invasiveness Laboratories Liver cancer Liver Neoplasms - immunology Liver Neoplasms - metabolism Liver Neoplasms - pathology Medicine Metastases Metastasis Molecular modelling Neoplasm Invasiveness Neoplasm Metastasis Neoplastic Stem Cells - immunology Peptides - immunology Polymerase Chain Reaction Proteins Receptors, Lysophosphatidic Acid - physiology Rodents Stem cells Tumors Xenografts
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