Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFNγ-induced STAT1 transcriptional activity

The protozoan Toxoplasma gondii actively modulates cytokine-induced JAK/STAT signaling pathways to facilitate survival within the host, including blocking IFNγ-mediated STAT1-dependent proinflammatory gene expression. We sought to further characterize inhibition of STAT1 signaling in infected murine...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e60215-e60215
Hauptverfasser:	Schneider, Anne G, Abi Abdallah, Delbert S, Butcher, Barbara A, Denkers, Eric Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Animals Binding Biology Bone marrow Cell Nucleus - metabolism Chromatin Immunoprecipitation Conserved sequence Cytokines Dendritic cells Dendritic Cells - metabolism Dendritic structure DNA Primers - genetics Electrophoretic Mobility Shift Assay Enzyme-Linked Immunosorbent Assay Female Fibroblasts Flow Cytometry Gene expression Immunoblotting Immunology Infections Inflammation Interferon regulatory factor 1 Interferon-gamma - metabolism Kinases Mice Mice, Inbred C57BL Nuclear transport Oligonucleotides Oligonucleotides - metabolism Parasites Phosphorylation Protein-Tyrosine Kinases - metabolism Proteins Protozoa Protozoan Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Rhoptry protein Rodents Signal Transduction - physiology Signaling Stat1 protein STAT1 Transcription Factor - metabolism STAT1 Transcription Factor - physiology Stat3 protein Stat6 protein Toxoplasma gondii Toxoplasmosis - metabolism Toxoplasmosis - physiopathology Transcription Transcription factors Transcription, Genetic - physiology Translocation Veterinary colleges Veterinary medicine γ-Interferon
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