RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming

Neutrophils are central to the pathology of inflammatory diseases, where they can damage host tissue through release of reactive oxygen metabolites and proteases, and drive inflammation via secretion of cytokines and chemokines. Many cytokines, such as those generated during inflammation, can induce...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e58598
Hauptverfasser:	Wright, Helen L, Thomas, Huw B, Moots, Robert J, Edwards, Steven W
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bioinformatics Biology Cell activation Cell surface Chemokines Chronic obstructive pulmonary disease Cytokines Cytokines - biosynthesis Cytokines - immunology Cytokines - pharmacology Disease DNA binding proteins Female Gene expression Genes Genomes Granulocyte-macrophage colony-stimulating factor Humans Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Inflammatory diseases Inhibition Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - immunology Interleukin 1 Interleukin 1 receptor antagonist Janus Kinases - immunology Janus Kinases - metabolism Kinases Leukocytes (neutrophilic) Male Medicine Metabolites Neutrophil Activation Neutrophils Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology NF-κB protein Oxygen Pathways Predictions Priming Proteases Receptors Rheumatoid arthritis Ribonucleic acid RNA RNA sequencing Signal Transduction Signaling STAT Transcription Factors - immunology STAT Transcription Factors - metabolism Transcription (Genetics) Transcription activation Transcription factors Transcriptome - drug effects Transcriptome - immunology Tumor necrosis factor Tumor necrosis factor-α
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