Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?

Epigenetics may play a role in the pathophysiology of type 2 diabetes (T2D), and increased DNA methylation of the metabolic master regulator peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) has been reported in muscle and pancreatic islets from T2D patients and in musc...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e58384-e58384
Hauptverfasser:	Gillberg, Linn, Jacobsen, Stine C, Jacobsen, Stine, Ribel-Madsen, Rasmus, Gjesing, Anette Prior, Boesgaard, Trine W, Ling, Charlotte, Pedersen, Oluf, Hansen, Torben, Vaag, Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biology Bisulfite Clinical Medicine CpG Islands Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism DNA DNA Methylation DNA sequencing Endocrinology Endocrinology and Diabetes Endokrinologi och diabetes Epigenetic inheritance Epigenetics Family medical history Female Gene expression Gene Expression Regulation Gene sequencing Genes Genetics Genomes Glucose Glucose tolerance Health sciences Heat-Shock Proteins - genetics Humans Insulin Insulin - metabolism Insulin resistance Insulin Resistance - genetics Klinisk medicin Male Medical and Health Sciences Medical research Medicin och hälsovetenskap Medicine Metabolism Methylation Middle Aged Muscle, Skeletal - metabolism Muscles Musculoskeletal system Nuclear Family Pancreas Patients Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Population Prediabetic state Promoter Regions, Genetic RNA RNA, Messenger - genetics Skeletal muscle Studies Sulfites Transcription Transcription Factors - genetics Type 2 diabetes
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