Polymorphisms in the calcium-sensing receptor gene are associated with clinical outcome of neuroblastoma

Neuroblastic tumors include the neuroblastomas, ganglioneuroblastomas, and ganglioneuromas. Clinical behavior of these developmental malignancies varies from regression to aggressive growth with metastatic dissemination. Several clinical, histological, genetic, and biological features are associated...

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Veröffentlicht in:	PLOS ONE 2013-03, Vol.8 (3), p.e59762-e59762
Hauptverfasser:	Masvidal, Laia, Iniesta, Raquel, Casalà, Carla, Galván, Patricia, Rodríguez, Eva, Lavarino, Cinzia, Mora, Jaume, de Torres, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Algorithms Biodiversity Biology Bone marrow Calcium Calcium homeostasis Calcium-sensing receptors Cancer Cancer metastasis Cellular signal transduction Clinical outcomes Confidence intervals Deactivation Deoxyribonucleic acid DNA Epigenetic inheritance Female G protein-coupled receptors Gene expression Genes Genetic aspects Genetic diversity Genetic polymorphisms Genetic variance Genotype Genotyping Haplotypes Homeostasis Humans Inactivation Laboratories Loci Male Medical diagnosis Medicine Metastases Mutation Neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology Patient outcomes Patients Polymorphism Polymorphism, Genetic - genetics Receptors, Calcium-Sensing - genetics Regression analysis Statistical analysis Subgroups Transduction Tumors Young Adult
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