Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity

To investigate the functional effects of probiotic treatment on the gut microbiota, as well as liver and adipose gene expression in diet-induced obese mice. Male C57BL/6J mice were fed a high-fat diet (HFD) for 8 weeks to induce obesity, and then randomized to receive HFD+probiotic (Lactobacillus cu...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59470
Hauptverfasser:	Park, Do-Young, Ahn, Young-Tae, Park, Se-Hoon, Huh, Chul-Sung, Yoo, Sae-Rom, Yu, Rina, Sung, Mi-Kyung, McGregor, Robin A, Choi, Myung-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - drug effects Adipocytes - metabolism Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose Tissue - pathology Animals Bacteria Biodiversity Biology Biomarkers Body weight Body Weight - drug effects Body weight gain Cholesterol Cholesterol - blood Diabetes Diet Diet - adverse effects Dietary supplements Fatty acids Fecal microflora Females Food science Gene expression Gene Expression Regulation - drug effects Genes Genomics High fat diet Hormones - blood Inflammation Insulin Interleukin 1 Interleukin 6 Intestinal microflora Intestines - drug effects Intestines - microbiology Lactobacillus plantarum Lactobacillus plantarum - physiology Leptin Lipids Liver Liver - drug effects Liver - metabolism Male Medicine Metabolism Metagenome - drug effects Mice Mice, Inbred C57BL Microbiota Microbiota (Symbiotic organisms) Microorganisms Nutrition research Obesity Obesity - diet therapy Obesity - etiology Obesity - metabolism Obesity - microbiology Oxidation Physiological aspects Probiotics Probiotics - pharmacology Probiotics - therapeutic use Reducing diets Rodents Studies Toxicity Transcription Tumor necrosis factor-α Weight control Weight reduction
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