Epidemiology and evolution of rotaviruses and noroviruses from an archival WHO Global Study in Children (1976-79) with implications for vaccine design

Prompted by the discovery of new gastrointestinal viruses, the NIH, NIAID and WHO investigated the etiology of acute diarrhea that occurred from 1976-1979 in a global cohort of infants and young children. Rotaviruses were found to be major pathogens worldwide, whereas the Norwalk virus could not be...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59394-e59394
Hauptverfasser:	Rackoff, Lauren A, Bok, Karin, Green, Kim Y, Kapikian, Albert Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antigens, Viral - genetics Biology Capsid Proteins - genetics Child Child, Preschool Children Developing countries Diarrhea Diarrhea - epidemiology Diarrhea - history Diarrhea - prevention & control Diarrhea - virology Epidemiology Etiology Evolution, Molecular Gastroenteritis - epidemiology Gastroenteritis - virology Genotype Genotypes Global Health History, 20th Century Humans Infant Infant, Newborn Infants Infectious diseases Laboratories LDCs Medicine Molecular Sequence Data Mortality Norovirus - classification Norovirus - genetics Norovirus - immunology Phylogenetics Phylogeny Polymerase chain reaction Proteins Radioimmunoassay RNA polymerase Rotavirus Rotavirus - classification Rotavirus - genetics Rotavirus - immunology Vaccines Viral Vaccines - immunology Viruses
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