CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1

Tourette syndrome (TS) is a neuropsychiatric disorder with a strong genetic component. However, the genetic architecture of TS remains uncertain. Copy number variation (CNV) has been shown to contribute to the genetic make-up of several neurodevelopmental conditions, including schizophrenia and auti...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59061-e59061
Hauptverfasser:	Nag, Abhishek, Bochukova, Elena G, Kremeyer, Barbara, Campbell, Desmond D, Muller, Heike, Valencia-Duarte, Ana V, Cardona, Julio, Rivas, Isabel C, Mesa, Sandra C, Cuartas, Mauricio, Garcia, Jharley, Bedoya, Gabriel, Cornejo, William, Herrera, Luis D, Romero, Roxana, Fournier, Eduardo, Reus, Victor I, Lowe, Thomas L, Farooqi, I Sadaf, Mathews, Carol A, McGrath, Lauren M, Yu, Dongmei, Cook, Ed, Wang, Kai, Scharf, Jeremiah M, Pauls, David L, Freimer, Nelson B, Plagnol, Vincent, Ruiz-Linares, Andrés
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Attention Deficit Hyperactivity Disorder Autism Biology Calcium-Binding Proteins Cell Adhesion Molecules, Neuronal - genetics Child Chromosomes Collagen (type VIII) Collagen Type IX - genetics Comparative analysis Copy number DNA Copy Number Variations - genetics Female Genes Genetic aspects Genetic Predisposition to Disease - genetics Genetics Genomes Genotype Genotypes Gilles de la Tourette syndrome Humans Laboratories Male Medicine Mental disorders Metabolism Mutation Nerve Tissue Proteins - genetics Nervous system Nervous system diseases Neural Cell Adhesion Molecules Neurodevelopmental disorders Obsessive compulsive disorder Parents Polymorphism, Single Nucleotide - genetics Population Principal components analysis Psychiatry Quality control Schizophrenia Single-nucleotide polymorphism Tourette syndrome Tourette Syndrome - etiology Tourette Syndrome - genetics
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