Resveratrol induces premature senescence in lung cancer cells via ROS-mediated DNA damage

Resveratrol (RV) is a natural component of red wine and grapes that has been shown to be a potential chemopreventive and anticancer agent. However, the molecular mechanisms underlying RV's anticancer and chemopreventive effects are incompletely understood. Here we show that RV treatment inhibit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e60065
Hauptverfasser:	Luo, Hongmei, Yang, Aimin, Schulte, Bradley A, Wargovich, Michael J, Wang, Gavin Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Anticancer properties Apoptosis Biology Blotting, Western Cancer Cancer cells Cancer genetics Cancer prevention Cancer therapies Cancer treatment Caspase Caspase-3 Cell cycle Cell Line, Tumor Cellular Senescence - drug effects Chemotherapy Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Drug dosages Fibroblasts Flow Cytometry Galactosidase Grapes Humans Ionizing radiation Laboratories Lung cancer Lung diseases Lung Neoplasms - genetics Medical prognosis Medicine Molecular modelling NAD(P)H oxidase Non-small cell lung cancer Non-small cell lung carcinoma Oxidative stress Oxygen p53 Protein Pathology Poly(ADP-ribose) polymerase Reactive oxygen species Reactive Oxygen Species - metabolism Respiratory system agents Resveratrol Reverse Transcriptase Polymerase Chain Reaction Senescence Stilbenes - pharmacology Tumor proteins Wine Wines β-Galactosidase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!