Interaction and inhibition of dengue envelope glycoprotein with mammalian receptor DC-sign, an in-silico approach

Membrane fusion is the central molecular event during the entry of enveloped viruses into cells. The critical agents of this process are viral surface proteins, primed to facilitate cell bilayer fusion. The important role of Dendritic-cell-specific ICAM3-grabbing non-integrin (DC-SIGN) in Dengue vir...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59211-e59211
Hauptverfasser:	Shah, Masaud, Wadood, Abdul, Rahman, Ziaur, Husnain, Tayyab
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Antibodies, Monoclonal - immunology Biochemistry Bioinformatics Biology Carbohydrates Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - immunology Cell fusion Computational Biology Computer Science Crystallography, X-Ray DC-SIGN protein Dendritic cells Dengue Dengue - prevention & control Dengue - transmission Dengue fever Dengue virus Dengue Virus - chemistry Dengue Virus - genetics Dengue Virus - immunology Dengue viruses Disease transmission Docking Encephalitis Endocytosis Epitopes, B-Lymphocyte - genetics Force distribution Glycoproteins Glycosylation Health aspects Humans Immunoglobulins Infections Integrins Laboratories Lectins, C-Type - chemistry Lectins, C-Type - immunology Ligands Likelihood Functions Medicine Membrane fusion Membranes Models, Genetic Models, Molecular Molecular biology Monoclonal antibodies Neural networks Pharmaceutical sciences Phylogeny Protein Binding Protein Folding Protein interaction Protein-protein interactions Proteins Receptors Receptors, Cell Surface - chemistry Receptors, Cell Surface - immunology Sequence Alignment Serotypes Stress concentration Tropical diseases Vector-borne diseases Viral diseases Viral envelope proteins Viral Envelope Proteins - genetics Virions Viruses
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