Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia

Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e59138-e59138
Hauptverfasser:	Wang, Zhuo, Ocampo, Marco A, Pang, Raina D, Bota, Mihail, Bradesi, Sylvie, Mayer, Emeran A, Holschneider, Daniel P
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Amygdala Animals Autoradiography Behavioral sciences Biology Blood flow Brain Brain - physiology Brain mapping Brain research Brain slice preparation Carbon 14 Cerebral blood flow Colon - physiology Connectivity Correlation Correlation analysis Cortex (insular) Distension Flow mapping Gastroenterology Hyperalgesia Hyperalgesia - etiology Hyperalgesia - physiopathology Hypothalamus Image reconstruction Intestine Intravenous administration Irritable bowel syndrome Laboratory animals Limbic System - physiology Male Medical imaging Medicine Motor Activity Neural networks Neurobiology Neuroimaging Neurosciences Pain Pain perception Perfusion Prefrontal cortex Prefrontal Cortex - physiology Psychiatry Radioactive tracers Radioactivity Rats Rectum - physiology Rodents Social and Behavioral Sciences Stress Stress (Psychology) Stress, Psychological Stresses
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