Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia
Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-03, Vol.8 (3), p.e59138-e59138 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e59138 |
|---|---|
| container_issue | 3 |
| container_start_page | e59138 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Wang, Zhuo Ocampo, Marco A Pang, Raina D Bota, Mihail Bradesi, Sylvie Mayer, Emeran A Holschneider, Daniel P |
| description | Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the onset and exacerbation of IBS symptoms. Little is known regarding central mechanisms underlying the stress-induced VH. Here, we applied an autoradiographic perfusion method to map regional and network-level neural correlates of VH. Adult male rats were exposed to WAS or sham treatment for 1 hour/day for 10 days. The visceromotor response was measured before and after the treatment. Cerebral blood flow (CBF) mapping was performed by intravenous injection of radiotracer ([(14)C]-iodoantipyrine) while the rat was receiving a 60-mmHg CRD or no distension. Regional CBF-related tissue radioactivity was quantified in autoradiographic images of brain slices and analyzed in 3-dimensionally reconstructed brains with statistical parametric mapping. Compared to sham rats, stressed rats showed VH in association with greater CRD-evoked activation in the insular cortex, amygdala, and hypothalamus, but reduced activation in the prelimbic area (PrL) of prefrontal cortex. We constrained results of seed correlation analysis by known structural connectivity of the PrL to generate structurally linked functional connectivity (SLFC) of the PrL. Dramatic differences in the SLFC of PrL were noted between stressed and sham rats under distension. In particular, sham rats showed negative correlation between the PrL and amygdala, which was absent in stressed rats. The altered pattern of functional brain activation is in general agreement with that observed in IBS patients in human brain imaging studies, providing further support for the face and construct validity of the WAS model for IBS. The absence of prefrontal cortex-amygdala anticorrelation in stressed rats is consistent with the notion that impaired corticolimbic modulation acts as a central mechanism underlying stress-induced VH. |
| doi_str_mv | 10.1371/journal.pone.0059138 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1330889438</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478207608</galeid><doaj_id>oai_doaj_org_article_b98ac2d31e4b4a11a5bf03f6fd42c718</doaj_id><sourcerecordid>A478207608</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-a3dab70f55241be05388b3a934dcb895bcdb97e1dac16bbe0a84bff4a443e1ee3</originalsourceid><addsrcrecordid>eNqNk9uK2zAQhk1p6R7aNyitobC0F04tSz7dFMLSQ2BhoadbMTo4UVCkrCWnzdtXSrxLXPai-EJi9P3_eEaaJHmF8hnCNfqwtkNvQM-21shZnpctws2T5By1uMiqIsdPT_ZnyYVz6wDhpqqeJ2cFLosaIXKe_J5rL3vwyhqXKpNue9n11njQmVYbpnjaDYbHY9AphM3uwKZgRMqtMTKGlN9HLV8FZVA430vnMmXEwKVId8rxkEKnq_02rkvpFLxInnWgnXw5rpfJz8-fflx_zW5uvyyu5zcZr9rCZ4AFsDrvyrIgiMlYQMMwtJgIzpq2ZFywtpZIAEcVCwA0hHUdAUKwRFLiy-TN0XerraNjzxxFGOdN0xLcBGJxJISFNd32agP9nlpQ9BCw_ZJC7xXXkrK2AV4IjCRhBBCCknU57qpOkILXKHp9HLMNbCMFl8aHgiem0xOjVnRpdxRXeVGSMhi8Gw16ezdI5-kmdk9rMNIO8b9RW6EaFVVA3_6DPl7dSC0hFKBMZ0NeHk3pnNRNkddVHqnZI1T4hNyocM2yUyE-EbyfCALj5R-_hME5uvj-7f_Z219T9uqEXUnQfuWsHg7vcwqSI8h761x4tA9NRjmN83HfDRrng47zEWSvTy_oQXQ_EPgvdEkOwQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1330889438</pqid></control><display><type>article</type><title>Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Wang, Zhuo ; Ocampo, Marco A ; Pang, Raina D ; Bota, Mihail ; Bradesi, Sylvie ; Mayer, Emeran A ; Holschneider, Daniel P</creator><creatorcontrib>Wang, Zhuo ; Ocampo, Marco A ; Pang, Raina D ; Bota, Mihail ; Bradesi, Sylvie ; Mayer, Emeran A ; Holschneider, Daniel P</creatorcontrib><description>Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the onset and exacerbation of IBS symptoms. Little is known regarding central mechanisms underlying the stress-induced VH. Here, we applied an autoradiographic perfusion method to map regional and network-level neural correlates of VH. Adult male rats were exposed to WAS or sham treatment for 1 hour/day for 10 days. The visceromotor response was measured before and after the treatment. Cerebral blood flow (CBF) mapping was performed by intravenous injection of radiotracer ([(14)C]-iodoantipyrine) while the rat was receiving a 60-mmHg CRD or no distension. Regional CBF-related tissue radioactivity was quantified in autoradiographic images of brain slices and analyzed in 3-dimensionally reconstructed brains with statistical parametric mapping. Compared to sham rats, stressed rats showed VH in association with greater CRD-evoked activation in the insular cortex, amygdala, and hypothalamus, but reduced activation in the prelimbic area (PrL) of prefrontal cortex. We constrained results of seed correlation analysis by known structural connectivity of the PrL to generate structurally linked functional connectivity (SLFC) of the PrL. Dramatic differences in the SLFC of PrL were noted between stressed and sham rats under distension. In particular, sham rats showed negative correlation between the PrL and amygdala, which was absent in stressed rats. The altered pattern of functional brain activation is in general agreement with that observed in IBS patients in human brain imaging studies, providing further support for the face and construct validity of the WAS model for IBS. The absence of prefrontal cortex-amygdala anticorrelation in stressed rats is consistent with the notion that impaired corticolimbic modulation acts as a central mechanism underlying stress-induced VH.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0059138</identifier><identifier>PMID: 23527114</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Amygdala ; Animals ; Autoradiography ; Behavioral sciences ; Biology ; Blood flow ; Brain ; Brain - physiology ; Brain mapping ; Brain research ; Brain slice preparation ; Carbon 14 ; Cerebral blood flow ; Colon - physiology ; Connectivity ; Correlation ; Correlation analysis ; Cortex (insular) ; Distension ; Flow mapping ; Gastroenterology ; Hyperalgesia ; Hyperalgesia - etiology ; Hyperalgesia - physiopathology ; Hypothalamus ; Image reconstruction ; Intestine ; Intravenous administration ; Irritable bowel syndrome ; Laboratory animals ; Limbic System - physiology ; Male ; Medical imaging ; Medicine ; Motor Activity ; Neural networks ; Neurobiology ; Neuroimaging ; Neurosciences ; Pain ; Pain perception ; Perfusion ; Prefrontal cortex ; Prefrontal Cortex - physiology ; Psychiatry ; Radioactive tracers ; Radioactivity ; Rats ; Rectum - physiology ; Rodents ; Social and Behavioral Sciences ; Stress ; Stress (Psychology) ; Stress, Psychological ; Stresses</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e59138-e59138</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Wang et al 2013 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a3dab70f55241be05388b3a934dcb895bcdb97e1dac16bbe0a84bff4a443e1ee3</citedby><cites>FETCH-LOGICAL-c692t-a3dab70f55241be05388b3a934dcb895bcdb97e1dac16bbe0a84bff4a443e1ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602545/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602545/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23527114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhuo</creatorcontrib><creatorcontrib>Ocampo, Marco A</creatorcontrib><creatorcontrib>Pang, Raina D</creatorcontrib><creatorcontrib>Bota, Mihail</creatorcontrib><creatorcontrib>Bradesi, Sylvie</creatorcontrib><creatorcontrib>Mayer, Emeran A</creatorcontrib><creatorcontrib>Holschneider, Daniel P</creatorcontrib><title>Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the onset and exacerbation of IBS symptoms. Little is known regarding central mechanisms underlying the stress-induced VH. Here, we applied an autoradiographic perfusion method to map regional and network-level neural correlates of VH. Adult male rats were exposed to WAS or sham treatment for 1 hour/day for 10 days. The visceromotor response was measured before and after the treatment. Cerebral blood flow (CBF) mapping was performed by intravenous injection of radiotracer ([(14)C]-iodoantipyrine) while the rat was receiving a 60-mmHg CRD or no distension. Regional CBF-related tissue radioactivity was quantified in autoradiographic images of brain slices and analyzed in 3-dimensionally reconstructed brains with statistical parametric mapping. Compared to sham rats, stressed rats showed VH in association with greater CRD-evoked activation in the insular cortex, amygdala, and hypothalamus, but reduced activation in the prelimbic area (PrL) of prefrontal cortex. We constrained results of seed correlation analysis by known structural connectivity of the PrL to generate structurally linked functional connectivity (SLFC) of the PrL. Dramatic differences in the SLFC of PrL were noted between stressed and sham rats under distension. In particular, sham rats showed negative correlation between the PrL and amygdala, which was absent in stressed rats. The altered pattern of functional brain activation is in general agreement with that observed in IBS patients in human brain imaging studies, providing further support for the face and construct validity of the WAS model for IBS. The absence of prefrontal cortex-amygdala anticorrelation in stressed rats is consistent with the notion that impaired corticolimbic modulation acts as a central mechanism underlying stress-induced VH.</description><subject>Activation</subject><subject>Amygdala</subject><subject>Animals</subject><subject>Autoradiography</subject><subject>Behavioral sciences</subject><subject>Biology</subject><subject>Blood flow</subject><subject>Brain</subject><subject>Brain - physiology</subject><subject>Brain mapping</subject><subject>Brain research</subject><subject>Brain slice preparation</subject><subject>Carbon 14</subject><subject>Cerebral blood flow</subject><subject>Colon - physiology</subject><subject>Connectivity</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Cortex (insular)</subject><subject>Distension</subject><subject>Flow mapping</subject><subject>Gastroenterology</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - physiopathology</subject><subject>Hypothalamus</subject><subject>Image reconstruction</subject><subject>Intestine</subject><subject>Intravenous administration</subject><subject>Irritable bowel syndrome</subject><subject>Laboratory animals</subject><subject>Limbic System - physiology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Motor Activity</subject><subject>Neural networks</subject><subject>Neurobiology</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Perfusion</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - physiology</subject><subject>Psychiatry</subject><subject>Radioactive tracers</subject><subject>Radioactivity</subject><subject>Rats</subject><subject>Rectum - physiology</subject><subject>Rodents</subject><subject>Social and Behavioral Sciences</subject><subject>Stress</subject><subject>Stress (Psychology)</subject><subject>Stress, Psychological</subject><subject>Stresses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9uK2zAQhk1p6R7aNyitobC0F04tSz7dFMLSQ2BhoadbMTo4UVCkrCWnzdtXSrxLXPai-EJi9P3_eEaaJHmF8hnCNfqwtkNvQM-21shZnpctws2T5By1uMiqIsdPT_ZnyYVz6wDhpqqeJ2cFLosaIXKe_J5rL3vwyhqXKpNue9n11njQmVYbpnjaDYbHY9AphM3uwKZgRMqtMTKGlN9HLV8FZVA430vnMmXEwKVId8rxkEKnq_02rkvpFLxInnWgnXw5rpfJz8-fflx_zW5uvyyu5zcZr9rCZ4AFsDrvyrIgiMlYQMMwtJgIzpq2ZFywtpZIAEcVCwA0hHUdAUKwRFLiy-TN0XerraNjzxxFGOdN0xLcBGJxJISFNd32agP9nlpQ9BCw_ZJC7xXXkrK2AV4IjCRhBBCCknU57qpOkILXKHp9HLMNbCMFl8aHgiem0xOjVnRpdxRXeVGSMhi8Gw16ezdI5-kmdk9rMNIO8b9RW6EaFVVA3_6DPl7dSC0hFKBMZ0NeHk3pnNRNkddVHqnZI1T4hNyocM2yUyE-EbyfCALj5R-_hME5uvj-7f_Z219T9uqEXUnQfuWsHg7vcwqSI8h761x4tA9NRjmN83HfDRrng47zEWSvTy_oQXQ_EPgvdEkOwQ</recordid><startdate>20130319</startdate><enddate>20130319</enddate><creator>Wang, Zhuo</creator><creator>Ocampo, Marco A</creator><creator>Pang, Raina D</creator><creator>Bota, Mihail</creator><creator>Bradesi, Sylvie</creator><creator>Mayer, Emeran A</creator><creator>Holschneider, Daniel P</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130319</creationdate><title>Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia</title><author>Wang, Zhuo ; Ocampo, Marco A ; Pang, Raina D ; Bota, Mihail ; Bradesi, Sylvie ; Mayer, Emeran A ; Holschneider, Daniel P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a3dab70f55241be05388b3a934dcb895bcdb97e1dac16bbe0a84bff4a443e1ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Activation</topic><topic>Amygdala</topic><topic>Animals</topic><topic>Autoradiography</topic><topic>Behavioral sciences</topic><topic>Biology</topic><topic>Blood flow</topic><topic>Brain</topic><topic>Brain - physiology</topic><topic>Brain mapping</topic><topic>Brain research</topic><topic>Brain slice preparation</topic><topic>Carbon 14</topic><topic>Cerebral blood flow</topic><topic>Colon - physiology</topic><topic>Connectivity</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Cortex (insular)</topic><topic>Distension</topic><topic>Flow mapping</topic><topic>Gastroenterology</topic><topic>Hyperalgesia</topic><topic>Hyperalgesia - etiology</topic><topic>Hyperalgesia - physiopathology</topic><topic>Hypothalamus</topic><topic>Image reconstruction</topic><topic>Intestine</topic><topic>Intravenous administration</topic><topic>Irritable bowel syndrome</topic><topic>Laboratory animals</topic><topic>Limbic System - physiology</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Motor Activity</topic><topic>Neural networks</topic><topic>Neurobiology</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Perfusion</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - physiology</topic><topic>Psychiatry</topic><topic>Radioactive tracers</topic><topic>Radioactivity</topic><topic>Rats</topic><topic>Rectum - physiology</topic><topic>Rodents</topic><topic>Social and Behavioral Sciences</topic><topic>Stress</topic><topic>Stress (Psychology)</topic><topic>Stress, Psychological</topic><topic>Stresses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhuo</creatorcontrib><creatorcontrib>Ocampo, Marco A</creatorcontrib><creatorcontrib>Pang, Raina D</creatorcontrib><creatorcontrib>Bota, Mihail</creatorcontrib><creatorcontrib>Bradesi, Sylvie</creatorcontrib><creatorcontrib>Mayer, Emeran A</creatorcontrib><creatorcontrib>Holschneider, Daniel P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhuo</au><au>Ocampo, Marco A</au><au>Pang, Raina D</au><au>Bota, Mihail</au><au>Bradesi, Sylvie</au><au>Mayer, Emeran A</au><au>Holschneider, Daniel P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-03-19</date><risdate>2013</risdate><volume>8</volume><issue>3</issue><spage>e59138</spage><epage>e59138</epage><pages>e59138-e59138</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the onset and exacerbation of IBS symptoms. Little is known regarding central mechanisms underlying the stress-induced VH. Here, we applied an autoradiographic perfusion method to map regional and network-level neural correlates of VH. Adult male rats were exposed to WAS or sham treatment for 1 hour/day for 10 days. The visceromotor response was measured before and after the treatment. Cerebral blood flow (CBF) mapping was performed by intravenous injection of radiotracer ([(14)C]-iodoantipyrine) while the rat was receiving a 60-mmHg CRD or no distension. Regional CBF-related tissue radioactivity was quantified in autoradiographic images of brain slices and analyzed in 3-dimensionally reconstructed brains with statistical parametric mapping. Compared to sham rats, stressed rats showed VH in association with greater CRD-evoked activation in the insular cortex, amygdala, and hypothalamus, but reduced activation in the prelimbic area (PrL) of prefrontal cortex. We constrained results of seed correlation analysis by known structural connectivity of the PrL to generate structurally linked functional connectivity (SLFC) of the PrL. Dramatic differences in the SLFC of PrL were noted between stressed and sham rats under distension. In particular, sham rats showed negative correlation between the PrL and amygdala, which was absent in stressed rats. The altered pattern of functional brain activation is in general agreement with that observed in IBS patients in human brain imaging studies, providing further support for the face and construct validity of the WAS model for IBS. The absence of prefrontal cortex-amygdala anticorrelation in stressed rats is consistent with the notion that impaired corticolimbic modulation acts as a central mechanism underlying stress-induced VH.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23527114</pmid><doi>10.1371/journal.pone.0059138</doi><tpages>e59138</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-03, Vol.8 (3), p.e59138-e59138 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1330889438 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activation Amygdala Animals Autoradiography Behavioral sciences Biology Blood flow Brain Brain - physiology Brain mapping Brain research Brain slice preparation Carbon 14 Cerebral blood flow Colon - physiology Connectivity Correlation Correlation analysis Cortex (insular) Distension Flow mapping Gastroenterology Hyperalgesia Hyperalgesia - etiology Hyperalgesia - physiopathology Hypothalamus Image reconstruction Intestine Intravenous administration Irritable bowel syndrome Laboratory animals Limbic System - physiology Male Medical imaging Medicine Motor Activity Neural networks Neurobiology Neuroimaging Neurosciences Pain Pain perception Perfusion Prefrontal cortex Prefrontal Cortex - physiology Psychiatry Radioactive tracers Radioactivity Rats Rectum - physiology Rodents Social and Behavioral Sciences Stress Stress (Psychology) Stress, Psychological Stresses |
| title | Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A44%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alterations%20in%20prefrontal-limbic%20functional%20activation%20and%20connectivity%20in%20chronic%20stress-induced%20visceral%20hyperalgesia&rft.jtitle=PloS%20one&rft.au=Wang,%20Zhuo&rft.date=2013-03-19&rft.volume=8&rft.issue=3&rft.spage=e59138&rft.epage=e59138&rft.pages=e59138-e59138&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0059138&rft_dat=%3Cgale_plos_%3EA478207608%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1330889438&rft_id=info:pmid/23527114&rft_galeid=A478207608&rft_doaj_id=oai_doaj_org_article_b98ac2d31e4b4a11a5bf03f6fd42c718&rfr_iscdi=true |