Regeneration of soft tissues is promoted by MMP1 treatment after digit amputation in mice
The ratio of matrix metalloproteinases (MMPs) to the tissue inhibitors of metalloproteinases (TIMPs) in wounded tissues strictly control the protease activity of MMPs, and therefore regulate the progress of wound closure, tissue regeneration and scar formation. Some amphibians (i.e. axolotl/newt) de...
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| description | The ratio of matrix metalloproteinases (MMPs) to the tissue inhibitors of metalloproteinases (TIMPs) in wounded tissues strictly control the protease activity of MMPs, and therefore regulate the progress of wound closure, tissue regeneration and scar formation. Some amphibians (i.e. axolotl/newt) demonstrate complete regeneration of missing or wounded digits and even limbs; MMPs play a critical role during amphibian regeneration. Conversely, mammalian wound healing re-establishes tissue integrity, but at the expense of scar tissue formation. The differences between amphibian regeneration and mammalian wound healing can be attributed to the greater ratio of MMPs to TIMPs in amphibian tissue. Previous studies have demonstrated the ability of MMP1 to effectively promote skeletal muscle regeneration by favoring extracellular matrix (ECM) remodeling to enhance cell proliferation and migration. In this study, MMP1 was administered to the digits amputated at the mid-second phalanx of adult mice to observe its effect on digit regeneration. Results indicated that the regeneration of soft tissue and the rate of wound closure were significantly improved by MMP1 administration, but the elongation of the skeletal tissue was insignificantly affected. During digit regeneration, more mutipotent progenitor cells, capillary vasculature and neuromuscular-related tissues were observed in MMP1 treated tissues; moreover, there was less fibrotic tissue formed in treated digits. In summary, MMP1 was found to be effective in promoting wound healing in amputated digits of adult mice. |
| doi_str_mv | 10.1371/journal.pone.0059105 |
| format | Article |
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Some amphibians (i.e. axolotl/newt) demonstrate complete regeneration of missing or wounded digits and even limbs; MMPs play a critical role during amphibian regeneration. Conversely, mammalian wound healing re-establishes tissue integrity, but at the expense of scar tissue formation. The differences between amphibian regeneration and mammalian wound healing can be attributed to the greater ratio of MMPs to TIMPs in amphibian tissue. Previous studies have demonstrated the ability of MMP1 to effectively promote skeletal muscle regeneration by favoring extracellular matrix (ECM) remodeling to enhance cell proliferation and migration. In this study, MMP1 was administered to the digits amputated at the mid-second phalanx of adult mice to observe its effect on digit regeneration. Results indicated that the regeneration of soft tissue and the rate of wound closure were significantly improved by MMP1 administration, but the elongation of the skeletal tissue was insignificantly affected. During digit regeneration, more mutipotent progenitor cells, capillary vasculature and neuromuscular-related tissues were observed in MMP1 treated tissues; moreover, there was less fibrotic tissue formed in treated digits. In summary, MMP1 was found to be effective in promoting wound healing in amputated digits of adult mice.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0059105</identifier><identifier>PMID: 23527099</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Ambystoma ; Amphibia ; Amphibians ; Amputation ; Amputation, Traumatic - drug therapy ; Amputation, Traumatic - pathology ; Animal tissues ; Animals ; Antigens, Ly - metabolism ; Biology ; Cell adhesion & migration ; Cell migration ; Cell proliferation ; Cells (biology) ; Cicatrix - prevention & control ; Collagen ; Digits ; Elongation ; Extracellular matrix ; Extremities - pathology ; Fibrosis ; Finger ; Gene expression ; Growth factors ; Laboratory animals ; Male ; Mammals ; Matrix Metalloproteinase 1 - administration & dosage ; Matrix Metalloproteinase 1 - pharmacology ; Matrix metalloproteinases ; Medical research ; Medicine ; Membrane Proteins - metabolism ; Mice ; Muscles ; Neovascularization, Physiologic - drug effects ; Neural Cell Adhesion Molecules - metabolism ; Pediatrics ; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism ; Progenitor cells ; Regeneration ; Regeneration - drug effects ; Rodents ; Salamandridae ; Scars ; Skeletal muscle ; Soft tissues ; Stem cells ; Stem Cells - drug effects ; Stem Cells - metabolism ; Surgery ; Time Factors ; Tissue engineering ; Tissue inhibitor of metalloproteinases ; Tissues ; Wound care ; Wound healing ; Wound Healing - drug effects</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e59105-e59105</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Mu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Mu et al 2013 Mu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-bf8bdb14f22703f473809400993ca9f0ddc6da38bb8d7bae6cefdf5f95202d773</citedby><cites>FETCH-LOGICAL-c725t-bf8bdb14f22703f473809400993ca9f0ddc6da38bb8d7bae6cefdf5f95202d773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601098/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601098/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23527099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Johnson, Rajasingh</contributor><creatorcontrib>Mu, Xiaodong</creatorcontrib><creatorcontrib>Bellayr, Ian</creatorcontrib><creatorcontrib>Pan, Haiying</creatorcontrib><creatorcontrib>Choi, Yohan</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><title>Regeneration of soft tissues is promoted by MMP1 treatment after digit amputation in mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The ratio of matrix metalloproteinases (MMPs) to the tissue inhibitors of metalloproteinases (TIMPs) in wounded tissues strictly control the protease activity of MMPs, and therefore regulate the progress of wound closure, tissue regeneration and scar formation. Some amphibians (i.e. axolotl/newt) demonstrate complete regeneration of missing or wounded digits and even limbs; MMPs play a critical role during amphibian regeneration. Conversely, mammalian wound healing re-establishes tissue integrity, but at the expense of scar tissue formation. The differences between amphibian regeneration and mammalian wound healing can be attributed to the greater ratio of MMPs to TIMPs in amphibian tissue. Previous studies have demonstrated the ability of MMP1 to effectively promote skeletal muscle regeneration by favoring extracellular matrix (ECM) remodeling to enhance cell proliferation and migration. In this study, MMP1 was administered to the digits amputated at the mid-second phalanx of adult mice to observe its effect on digit regeneration. Results indicated that the regeneration of soft tissue and the rate of wound closure were significantly improved by MMP1 administration, but the elongation of the skeletal tissue was insignificantly affected. During digit regeneration, more mutipotent progenitor cells, capillary vasculature and neuromuscular-related tissues were observed in MMP1 treated tissues; moreover, there was less fibrotic tissue formed in treated digits. In summary, MMP1 was found to be effective in promoting wound healing in amputated digits of adult mice.</description><subject>Ambystoma</subject><subject>Amphibia</subject><subject>Amphibians</subject><subject>Amputation</subject><subject>Amputation, Traumatic - drug therapy</subject><subject>Amputation, Traumatic - pathology</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Antigens, Ly - metabolism</subject><subject>Biology</subject><subject>Cell adhesion & migration</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Cells (biology)</subject><subject>Cicatrix - prevention & control</subject><subject>Collagen</subject><subject>Digits</subject><subject>Elongation</subject><subject>Extracellular matrix</subject><subject>Extremities - pathology</subject><subject>Fibrosis</subject><subject>Finger</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Mammals</subject><subject>Matrix Metalloproteinase 1 - administration & dosage</subject><subject>Matrix Metalloproteinase 1 - pharmacology</subject><subject>Matrix metalloproteinases</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Muscles</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Neural Cell Adhesion Molecules - metabolism</subject><subject>Pediatrics</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - metabolism</subject><subject>Progenitor cells</subject><subject>Regeneration</subject><subject>Regeneration - drug effects</subject><subject>Rodents</subject><subject>Salamandridae</subject><subject>Scars</subject><subject>Skeletal muscle</subject><subject>Soft tissues</subject><subject>Stem cells</subject><subject>Stem Cells - drug effects</subject><subject>Stem Cells - metabolism</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Tissue engineering</subject><subject>Tissue inhibitor of metalloproteinases</subject><subject>Tissues</subject><subject>Wound care</subject><subject>Wound healing</subject><subject>Wound Healing - 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drug therapy</topic><topic>Amputation, Traumatic - pathology</topic><topic>Animal tissues</topic><topic>Animals</topic><topic>Antigens, Ly - metabolism</topic><topic>Biology</topic><topic>Cell adhesion & migration</topic><topic>Cell migration</topic><topic>Cell proliferation</topic><topic>Cells (biology)</topic><topic>Cicatrix - prevention & control</topic><topic>Collagen</topic><topic>Digits</topic><topic>Elongation</topic><topic>Extracellular matrix</topic><topic>Extremities - pathology</topic><topic>Fibrosis</topic><topic>Finger</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Mammals</topic><topic>Matrix Metalloproteinase 1 - administration & dosage</topic><topic>Matrix Metalloproteinase 1 - pharmacology</topic><topic>Matrix metalloproteinases</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Muscles</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Neural Cell Adhesion Molecules - metabolism</topic><topic>Pediatrics</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - metabolism</topic><topic>Progenitor cells</topic><topic>Regeneration</topic><topic>Regeneration - drug effects</topic><topic>Rodents</topic><topic>Salamandridae</topic><topic>Scars</topic><topic>Skeletal muscle</topic><topic>Soft tissues</topic><topic>Stem cells</topic><topic>Stem Cells - drug effects</topic><topic>Stem Cells - metabolism</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Tissue engineering</topic><topic>Tissue inhibitor of metalloproteinases</topic><topic>Tissues</topic><topic>Wound care</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mu, Xiaodong</creatorcontrib><creatorcontrib>Bellayr, Ian</creatorcontrib><creatorcontrib>Pan, Haiying</creatorcontrib><creatorcontrib>Choi, Yohan</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Some amphibians (i.e. axolotl/newt) demonstrate complete regeneration of missing or wounded digits and even limbs; MMPs play a critical role during amphibian regeneration. Conversely, mammalian wound healing re-establishes tissue integrity, but at the expense of scar tissue formation. The differences between amphibian regeneration and mammalian wound healing can be attributed to the greater ratio of MMPs to TIMPs in amphibian tissue. Previous studies have demonstrated the ability of MMP1 to effectively promote skeletal muscle regeneration by favoring extracellular matrix (ECM) remodeling to enhance cell proliferation and migration. In this study, MMP1 was administered to the digits amputated at the mid-second phalanx of adult mice to observe its effect on digit regeneration. Results indicated that the regeneration of soft tissue and the rate of wound closure were significantly improved by MMP1 administration, but the elongation of the skeletal tissue was insignificantly affected. During digit regeneration, more mutipotent progenitor cells, capillary vasculature and neuromuscular-related tissues were observed in MMP1 treated tissues; moreover, there was less fibrotic tissue formed in treated digits. In summary, MMP1 was found to be effective in promoting wound healing in amputated digits of adult mice.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23527099</pmid><doi>10.1371/journal.pone.0059105</doi><tpages>e59105</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Ambystoma Amphibia Amphibians Amputation Amputation, Traumatic - drug therapy Amputation, Traumatic - pathology Animal tissues Animals Antigens, Ly - metabolism Biology Cell adhesion & migration Cell migration Cell proliferation Cells (biology) Cicatrix - prevention & control Collagen Digits Elongation Extracellular matrix Extremities - pathology Fibrosis Finger Gene expression Growth factors Laboratory animals Male Mammals Matrix Metalloproteinase 1 - administration & dosage Matrix Metalloproteinase 1 - pharmacology Matrix metalloproteinases Medical research Medicine Membrane Proteins - metabolism Mice Muscles Neovascularization, Physiologic - drug effects Neural Cell Adhesion Molecules - metabolism Pediatrics Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Progenitor cells Regeneration Regeneration - drug effects Rodents Salamandridae Scars Skeletal muscle Soft tissues Stem cells Stem Cells - drug effects Stem Cells - metabolism Surgery Time Factors Tissue engineering Tissue inhibitor of metalloproteinases Tissues Wound care Wound healing Wound Healing - drug effects |
| title | Regeneration of soft tissues is promoted by MMP1 treatment after digit amputation in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T11%3A23%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regeneration%20of%20soft%20tissues%20is%20promoted%20by%20MMP1%20treatment%20after%20digit%20amputation%20in%20mice&rft.jtitle=PloS%20one&rft.au=Mu,%20Xiaodong&rft.date=2013-03-18&rft.volume=8&rft.issue=3&rft.spage=e59105&rft.epage=e59105&rft.pages=e59105-e59105&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0059105&rft_dat=%3Cgale_plos_%3EA478225128%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1330889405&rft_id=info:pmid/23527099&rft_galeid=A478225128&rft_doaj_id=oai_doaj_org_article_2439dbd87e8d4ab5a9e921f93d97be77&rfr_iscdi=true |