TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion

Toll like receptor 4 (TLR4) is an important pattern recognition receptor with the ability to drive potent innate immune responses and also to modulate adaptive immune responses needed for long term protection. Activation of TLR4 by its ligands is mediated by engagement of the adapter proteins MyD88...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e56855
Hauptverfasser:	Gandhapudi, Siva K, Chilton, Paula M, Mitchell, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adapters Adaptive immunity Adaptor proteins Adaptor Proteins, Vesicular Transport - deficiency Adaptor Proteins, Vesicular Transport - metabolism Adjuvants Adjuvants, Immunologic - pharmacology Adoptive transfer Animals Antigens Biological response modifiers Biology CD40 antigen CD80 antigen CD86 antigen Cell Division - drug effects Cell Division - immunology Cell proliferation Cell Proliferation - drug effects Cell survival Chemokines - metabolism Clone Cells - cytology Clone Cells - drug effects Clone Cells - immunology Clone Cells - metabolism Cytokines Defects Dendritic cells Drug dosages Gene expression Immune response Immune system Inflammation Innate immunity Interferon Interferon Type I - metabolism Interleukin 1 Kinases Lipid A Lipid A - pharmacology Lipids Lipopolysaccharides Lymphocytes Lymphocytes T Maturation Medicine Mice MyD88 protein Pattern recognition Pattern recognition receptors Priming Proteins Signal Transduction - drug effects Signal Transduction - immunology Signaling Spleen Stimulation T cells T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism TLR4 protein Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - metabolism Toll-like receptors Vaccines β-Interferon
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