Butyrate attenuates lipopolysaccharide-induced inflammation in intestinal cells and Crohn's mucosa through modulation of antioxidant defense machinery

Oxidative stress plays an important role in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease (CrD). High levels of Reactive Oxygen Species (ROS) induce the activation of the redox-sensitive nuclear transcription factor kappa-B (NF-κB), which in turn triggers the i...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e32841
Hauptverfasser:	Russo, Ilaria, Luciani, Alessandro, De Cicco, Paola, Troncone, Edoardo, Ciacci, Carolina
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adolescent Adult Antioxidants Antioxidants (Nutrients) Antioxidants - metabolism Biology Butyrates - pharmacology Catalysis Catalysis - drug effects Catalytic activity Cell Line Colon Confocal microscopy Crohn Disease - immunology Crohn Disease - pathology Crohn's Disease Crohns disease Cyclooxygenase-2 E coli Enzyme Activation - drug effects Epithelial cells Escherichia coli Esters Gastroenterology Gastrointestinal diseases Gene expression Gene Expression - drug effects Glutathione Transferase - genetics Humans Immune system Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory response Intercellular adhesion molecule 1 Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intestine Intracellular Isoenzymes - genetics Kinases Lamina propria Leukocytes (mononuclear) Lipopolysaccharides Lipopolysaccharides - immunology Machinery and equipment MAP kinase Medicine Metabolism Microscopy Mitogens Mucosa NF-kappa B - metabolism NF-κB protein Oxidation-Reduction Oxidative Stress Oxygen Pathogenesis Patients Phosphorylation Proteins Reactive oxygen species Reactive Oxygen Species - metabolism RNA RNA, Messenger - metabolism Rodents Studies Young Adult
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