Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes

Established cancers are frequently associated with a lymphocytic infiltrate that fails to clear the tumour mass. In contrast, the importance of recruited lymphocytes during premalignancy is less well understood. In a mouse model of premalignant skin epithelium, transgenic mice that express the human...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e57798-e57798
Hauptverfasser:	Choyce, Allison, Yong, Michelle, Narayan, Sharmal, Mattarollo, Stephen R, Liem, Amy, Lambert, Paul F, Frazer, Ian H, Leggatt, Graham R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biology Cancer Cancer therapies CCR6 protein CD4 antigen CD8 antigen Cell Count Cell cycle Chemokines E7 protein Epidermis Epithelium Epithelium - immunology Epithelium - metabolism Epithelium - pathology Flow cytometry Gene Expression Regulation Grafts Human papillomavirus Human papillomavirus 16 Hyperplasia Hyperplasia - immunology Hyperplasia - metabolism Immune Tolerance Immunosuppression Inflammation Keratin Laboratories Lymphocytes Lymphocytes T Medical research Medicine Mice Oncoproteins Papillomavirus E7 Proteins - chemistry Papillomavirus E7 Proteins - metabolism Plastic surgery Proteins Public health Retina Retinoblastoma Retinoblastoma Protein - metabolism Rodents Skin Skin - cytology Skin - immunology Skin - metabolism Skin - pathology Skin grafts T-Lymphocytes - cytology T-Lymphocytes - immunology Transgenic animals Transgenic mice Tumor Microenvironment - immunology Tumors
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