Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the ao...
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| Veröffentlicht in: | PloS one 2013-02, Vol.8 (2), p.e57398-e57398 |
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| creator | Tanaka, Hiroki Zaima, Nobuhiro Sasaki, Takeshi Hayasaka, Takahiro Goto-Inoue, Naoko Onoue, Kenji Ikegami, Koji Morita, Yoshifumi Yamamoto, Naoto Mano, Yuuki Sano, Masaki Saito, Takaaki Sato, Kohji Konno, Hiroyuki Setou, Mitsutoshi Unno, Naoki |
| description | Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease. |
| doi_str_mv | 10.1371/journal.pone.0057398 |
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However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0057398</identifier><identifier>PMID: 23460850</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adventitia - pathology ; Aged ; Aged, 80 and over ; Aneurysm ; Aneurysms ; Aorta ; Aortic Aneurysm, Abdominal - complications ; Aortic Aneurysm, Abdominal - pathology ; Aortic aneurysms ; Arteriosclerosis ; Arteriosclerosis - complications ; Arteriosclerosis - pathology ; Atherosclerosis ; Biology ; Cell proliferation ; Coronary vessels ; Female ; Geriatrics ; Growth factors ; Heme - metabolism ; Humans ; Hyperplasia ; Hypoxia ; Immunohistochemistry ; Lipids - chemistry ; Male ; Mass spectrometry ; Medical imaging ; Medicine ; Middle Aged ; Muscles ; Neck ; Neurosciences ; Nutrients ; Older people ; Oxygen ; Pathogenesis ; Patients ; Perfusion ; Rodents ; Scientific imaging ; Smooth muscle ; Stenosis ; Surgery ; Thrombosis ; Vasa Vasorum - pathology</subject><ispartof>PloS one, 2013-02, Vol.8 (2), p.e57398-e57398</ispartof><rights>2013 Tanaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Tanaka et al 2013 Tanaka et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-5089b0256778ceba9cc3abaa2deba6c742e8951554bf3400af35257185e2a6783</citedby><cites>FETCH-LOGICAL-c526t-5089b0256778ceba9cc3abaa2deba6c742e8951554bf3400af35257185e2a6783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583902/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583902/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23460850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aikawa, Elena</contributor><creatorcontrib>Tanaka, Hiroki</creatorcontrib><creatorcontrib>Zaima, Nobuhiro</creatorcontrib><creatorcontrib>Sasaki, Takeshi</creatorcontrib><creatorcontrib>Hayasaka, Takahiro</creatorcontrib><creatorcontrib>Goto-Inoue, Naoko</creatorcontrib><creatorcontrib>Onoue, Kenji</creatorcontrib><creatorcontrib>Ikegami, Koji</creatorcontrib><creatorcontrib>Morita, Yoshifumi</creatorcontrib><creatorcontrib>Yamamoto, Naoto</creatorcontrib><creatorcontrib>Mano, Yuuki</creatorcontrib><creatorcontrib>Sano, Masaki</creatorcontrib><creatorcontrib>Saito, Takaaki</creatorcontrib><creatorcontrib>Sato, Kohji</creatorcontrib><creatorcontrib>Konno, Hiroyuki</creatorcontrib><creatorcontrib>Setou, Mitsutoshi</creatorcontrib><creatorcontrib>Unno, Naoki</creatorcontrib><title>Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease.</description><subject>Abdomen</subject><subject>Adventitia - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneurysm</subject><subject>Aneurysms</subject><subject>Aorta</subject><subject>Aortic Aneurysm, Abdominal - complications</subject><subject>Aortic Aneurysm, Abdominal - pathology</subject><subject>Aortic aneurysms</subject><subject>Arteriosclerosis</subject><subject>Arteriosclerosis - complications</subject><subject>Arteriosclerosis - pathology</subject><subject>Atherosclerosis</subject><subject>Biology</subject><subject>Cell proliferation</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Growth factors</subject><subject>Heme - metabolism</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Hypoxia</subject><subject>Immunohistochemistry</subject><subject>Lipids - chemistry</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Muscles</subject><subject>Neck</subject><subject>Neurosciences</subject><subject>Nutrients</subject><subject>Older people</subject><subject>Oxygen</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Rodents</subject><subject>Scientific imaging</subject><subject>Smooth muscle</subject><subject>Stenosis</subject><subject>Surgery</subject><subject>Thrombosis</subject><subject>Vasa Vasorum - pathology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUstq3DAUFaUlSSf5g9IauulmpnpYr00hhOYBgW6atbiW5VSDbE0leyB_HznjhKQUofe5514dHYQ-EbwhTJLv2zilAcJmFwe3wZhLptU7dEI0o2tBMXv_an2MPua8LSCmhDhCx5TVAiuOT9Dlebt3w-hHD6HaQ4Z5iGnqK0ijSz5mG1yK2efKDxU0bex9yVpBTKO3FQxuSg-5P0UfOgjZnS3zCt1d_vx9cb2-_XV1c3F-u7acinHNsdINplxIqaxrQFvLoAGgbdkIK2vqlOaE87rpWI0xdIxTLonijoKQiq3QlwPvLsRsFgmyIYxhpZ76Ct0cEG2Erdkl30N6MBG8eTqI6d7AXHpwpqiASwml1bxuRac0aM06onFjJeWkcP1Ysk1N71pbhEoQ3pC-vRn8H3Mf94ZxxTSmheDbQpDi38nl0fQ-WxdC0S1Oc92kVppJLQr06z_Q_7-uPqBs-ZOcXPdSDMFmtsVzlJltYRZblLDPrx_yEvTsA_YIbAq2DQ</recordid><startdate>20130227</startdate><enddate>20130227</enddate><creator>Tanaka, Hiroki</creator><creator>Zaima, Nobuhiro</creator><creator>Sasaki, Takeshi</creator><creator>Hayasaka, Takahiro</creator><creator>Goto-Inoue, Naoko</creator><creator>Onoue, Kenji</creator><creator>Ikegami, Koji</creator><creator>Morita, Yoshifumi</creator><creator>Yamamoto, Naoto</creator><creator>Mano, Yuuki</creator><creator>Sano, Masaki</creator><creator>Saito, Takaaki</creator><creator>Sato, Kohji</creator><creator>Konno, Hiroyuki</creator><creator>Setou, Mitsutoshi</creator><creator>Unno, Naoki</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130227</creationdate><title>Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm</title><author>Tanaka, Hiroki ; Zaima, Nobuhiro ; Sasaki, Takeshi ; Hayasaka, Takahiro ; Goto-Inoue, Naoko ; Onoue, Kenji ; Ikegami, Koji ; Morita, Yoshifumi ; Yamamoto, Naoto ; Mano, Yuuki ; Sano, Masaki ; Saito, Takaaki ; Sato, Kohji ; Konno, Hiroyuki ; Setou, Mitsutoshi ; Unno, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-5089b0256778ceba9cc3abaa2deba6c742e8951554bf3400af35257185e2a6783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdomen</topic><topic>Adventitia - 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However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23460850</pmid><doi>10.1371/journal.pone.0057398</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-02, Vol.8 (2), p.e57398-e57398 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Adventitia - pathology Aged Aged, 80 and over Aneurysm Aneurysms Aorta Aortic Aneurysm, Abdominal - complications Aortic Aneurysm, Abdominal - pathology Aortic aneurysms Arteriosclerosis Arteriosclerosis - complications Arteriosclerosis - pathology Atherosclerosis Biology Cell proliferation Coronary vessels Female Geriatrics Growth factors Heme - metabolism Humans Hyperplasia Hypoxia Immunohistochemistry Lipids - chemistry Male Mass spectrometry Medical imaging Medicine Middle Aged Muscles Neck Neurosciences Nutrients Older people Oxygen Pathogenesis Patients Perfusion Rodents Scientific imaging Smooth muscle Stenosis Surgery Thrombosis Vasa Vasorum - pathology |
| title | Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T21%3A19%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adventitial%20vasa%20vasorum%20arteriosclerosis%20in%20abdominal%20aortic%20aneurysm&rft.jtitle=PloS%20one&rft.au=Tanaka,%20Hiroki&rft.date=2013-02-27&rft.volume=8&rft.issue=2&rft.spage=e57398&rft.epage=e57398&rft.pages=e57398-e57398&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0057398&rft_dat=%3Cproquest_plos_%3E2949767571%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1330883088&rft_id=info:pmid/23460850&rft_doaj_id=oai_doaj_org_article_2340a9c9c9454d6f89a993f190bc7251&rfr_iscdi=true |