CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival

CD133/Prominin-1 is a pentaspan transmembrane protein that has been frequently used as a biomarker for cancer stem cells, although its biological function is unclear. The aim of our study was to explore the intrinsic functions of CD133 membrane protein in hepatoma cells during autophagy, apoptosis,...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e56878
Hauptverfasser:	Chen, Haiyang, Luo, Zaili, Dong, Liwei, Tan, Yexiong, Yang, Jiamei, Feng, Gensheng, Wu, Mengchao, Li, Zhong, Wang, Hongyang
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Allografts Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - toxicity Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biology Biomarkers Cancer Cancer research Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell death Cell Line, Tumor Cell proliferation Cell Survival Cytoplasm Glucose Glucose - metabolism Glycoproteins - genetics Glycoproteins - immunology Glycoproteins - metabolism Hepatocellular carcinoma Hepatoma Hospitals Hostages Humans Hypoxia Immunofluorescence International cooperation Kinases Laboratories Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Lysosomes - metabolism Male Medicine Membrane proteins Mice Peptides - genetics Peptides - immunology Peptides - metabolism Phagocytosis Phagosomes - metabolism Proteins Signal transduction Starvation Stem cell transplantation Stem cells Surgery Survival Translocation Transplantation, Heterologous Tumorigenesis Tumors Xenografts
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