Neoplastic and stromal cells contribute to an extracellular matrix gene expression profile defining a breast cancer subtype likely to progress

We recently showed that differential expression of extracellular matrix (ECM) genes delineates four subgroups of breast carcinomas (ECM1, -2, -3- and -4) with different clinical outcome. To further investigate the characteristics of ECM signature and its impact on tumor progression, we conducted uns...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e56761
Hauptverfasser:	Triulzi, Tiziana, Casalini, Patrizia, Sandri, Marco, Ratti, Manuela, Carcangiu, Maria L, Colombo, Mario P, Balsari, Andrea, Ménard, Sylvie, Orlandi, Rosaria, Tagliabue, Elda
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Aged Algorithms Analysis Antineoplastic agents Biology Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cancer genetics Cell adhesion & migration Cell Line, Tumor Cell survival Cloning Cluster Analysis Clustering Collagen Computer Science Datasets Development and progression Disease Progression Enrichment Enzymes Estrogen receptors Extracellular matrix Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Fibroblasts Gene expression Gene Expression Regulation, Neoplastic Gene set enrichment analysis Genes Genetic aspects Growth factors Humans Invasiveness Mathematics Medicine Mesenchyme Metastases Metastasis Middle Aged Multivariate analysis Neoplasm Grading Oncology Prognosis Proteins Quality Sex hormones Stromal cells Stromal Cells - metabolism Stromal Cells - pathology Subgroups Survival Transcriptome Transforming growth factors Tumor Burden Tumor cell lines Tumors
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