Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds

Centratherum anthelminticum (L.) seeds (CA) is a well known medicinal herb in Indian sub-continent. We recently reported anti-oxidant property of chloroform fraction of Centratherum anthelminticum (L.) seeds (CACF) by inhibiting tumor necrosis factor-α (TNF-α)-induced growth of human breast cancer c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e56643
Hauptverfasser:	Looi, Chung Yeng, Arya, Aditya, Cheah, Foo Kit, Muharram, Bushra, Leong, Kok Hoong, Mohamad, Khalit, Wong, Won Fen, Rai, Nitika, Mustafa, Mohd Rais
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthelmintic agents Antineoplastic Agents - administration & dosage Apoptosis Apoptosis - drug effects Bcl-2 protein Bcl-x protein Bioassays Biology Brain cancer Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Cancer cells Cancer therapies Cancer treatment Caspase Caspases - drug effects Caspases - metabolism Cell cycle Cell Cycle Checkpoints - drug effects Cell death Cell growth Cell Proliferation - drug effects Cell size Centratherum anthelminticum Chemistry Chemotherapy Chinese medicine Chloroform Chromatography Cytochrome Cytochrome c Cytoskeleton Cytosol Cytotoxicity Deformation mechanisms Deoxyribonucleic acid DNA DNA damage DNA fragmentation DNA Fragmentation - drug effects DNA structure Female Females Fractionation Health aspects Herbal medicine High-performance liquid chromatography Humans Liquid chromatography Mass spectrometry MCF-7 Cells Medicinal plants Medicine Membrane potential Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria - drug effects NMR Nuclear magnetic resonance Oxidizing agents Oxygen Pharmacology Pharmacy Plant Extracts - chemistry Poly(ADP-ribose) polymerase Reactive oxygen species Reactive Oxygen Species - metabolism Scientific imaging Seeds Seeds - chemistry Sesquiterpenes - administration & dosage Sesquiterpenes - isolation & purification Shrinkage Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!