Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice

Long-term and unresolved airway inflammation and airway remodeling, characteristic features of chronic asthma, if not treated could lead to permanent structural changes in the airways. Aldose reductase (AR), an aldo-sugar and lipid aldehyde metabolizing enzyme, mediates allergen-induced airway infla...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e57442-e57442
Hauptverfasser:	Yadav, Umesh C S, Naura, Amarjit S, Aguilera-Aguirre, Leopoldo, Boldogh, Istvan, Boulares, Hamid A, Calhoun, William J, Ramana, Kota V, Srivastava, Satish K
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Actin Airway management Airway Remodeling - drug effects AKT protein Aldehyde reductase Aldehyde Reductase - antagonists & inhibitors Aldehyde Reductase - metabolism Allergens Allergies Animals Asthma Asthma - drug therapy Asthma - enzymology Biochemistry Biology Biomarkers - metabolism Cancer Chemokines Chronic Disease Chronic illnesses Collagen Cytokines Deposition Disease Models, Animal Drinking water E-cadherin Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Epithelial cells Epithelial Cells - drug effects Epithelial Cells - enzymology Epithelial Cells - pathology Epithelial-Mesenchymal Transition - drug effects Experiments Fibroblasts Fibronectin Gelatinase A Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Growth factors Health sciences Humans Hypersensitivity - enzymology Hypersensitivity - pathology Hypersensitivity - physiopathology Imidazolidines - pharmacology Imidazolidines - therapeutic use Immunology Infiltration Inflammation Inflammation - pathology Inhibition Inhibitors Kinases Lung - enzymology Lung - pathology Lungs Medical research Medicine Mesenchyme Metaplasia Methacholine Mice Molecular biology Mucus - secretion Muscles Ovalbumin Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Respiratory tract Respiratory tract diseases Rodents Signal Transduction - drug effects Smad protein Smad Proteins - metabolism Smooth muscle Studies Sugar Thickening Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1
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