Targeting anti-inflammatory treatment can ameliorate injury-induced neuropathic pain

Tumor necrosis factor-α plays important roles in immune system development, immune response regulation, and T-cell-mediated tissue injury. The present study assessed the net value of anti-tumor necrosis factor-α treatment in terms of functional recovery and inhibition of hypersensitivity after perip...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e57721
Hauptverfasser:	Iwatsuki, Katsuyuki, Arai, Tetsuya, Ota, Hideyuki, Kato, Shuichi, Natsume, Tadahiro, Kurimoto, Shigeru, Yamamoto, Michiro, Hirata, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Axons - drug effects Axons - physiology Behavior, Animal - drug effects Biology Crushing Cytokines Degeneration Electrophysiological Phenomena - drug effects Etanercept Fuel consumption Guillain-Barre syndrome Hand surgery Hyperalgesia - complications Hyperalgesia - drug therapy Hypersensitivity Immune response Immune response (cell-mediated) Immune system Immunoglobulin G - pharmacology Immunoglobulin G - therapeutic use Inflammation Injuries Interleukin Interleukin 6 Interleukin-6 - biosynthesis Interleukin-6 - genetics Lymphocytes T Macrophages Macrophages - drug effects Macrophages - metabolism Medicine Monocyte chemoattractant protein 1 Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscles Nerve conduction Nerves Nervous system Neuralgia - complications Neuralgia - drug therapy Neuralgia - metabolism Neuralgia - physiopathology Neurodegeneration Neurons Neuropathy Organ Size - drug effects Pain Peripheral Nerve Injuries - complications Peripheral nerves Peripheral neuropathy Rats Receptors, Tumor Necrosis Factor - therapeutic use Recovery Recovery of function Regeneration - drug effects Researchers RNA, Messenger - genetics RNA, Messenger - metabolism Sciatic nerve Skin Surgery Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF Tumor necrosis factor-α University graduates Wallerian Degeneration - complications
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