Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3+ regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is an inflammatory disease of the intestine in premature infants. Lactobacillus reuteri DSM 17938 improves survival and reduces the incidence and severity of NEC in a rodent model. Foxp3(+) regulatory T cells (Tregs) maintain intestinal homeostasis by controlling infl...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e56547
Hauptverfasser:	Liu, Yuying, Fatheree, Nicole Y, Dingle, Bridgette M, Tran, Dat Q, Rhoads, Jon Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Bacteria Biology Breast milk Breastfeeding & lactation CD3 antigen CD4 antigen CD8 antigen Cell surface Cytometry Enterocolitis Enterocolitis - chemically induced Enterocolitis - metabolism Enterocolitis - pathology Feeding Flow cytometry Forkhead Transcription Factors - metabolism Foxp3 protein Gastroenterology Gastrointestinal diseases Homeostasis Hypoxia Ileum Immune response Immune system Immunological tolerance Immunology Immunomodulation Immunoregulation Infants Inflammation - drug therapy Inflammation - immunology Inflammation - metabolism Intestinal Mucosa - metabolism Intestine Intestines - drug effects Intestines - immunology Lactobacillus reuteri Lactobacillus reuteri - chemistry Leukocyte migration Lupus Lymph Lymph nodes Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic system Lymphocytes Lymphocytes T Medical schools Medicine Mesentery - drug effects Mesentery - immunology Mesentery - metabolism Mesentery - pathology Milk Necrosis Necrotizing enterocolitis Neonates Newborn babies Pediatrics Probiotics Probiotics - administration & dosage Probiotics - chemistry Rats Rats, Sprague-Dawley Rodents Science Small intestine Spleen Surface markers T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Thymus
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