Effects of sertraline and fluoxetine on p-glycoprotein at barrier sites: in vivo and in vitro approaches

Retention of substances from systemic circulation in the brain and testes are limited due to high levels of P-glycoprotein (P-gp) in the luminal membranes of brain and testes capillary endothelial cells. From a clinical perspective, P-gp rapidly extrudes lipophilic therapeutic agents, which then fai...

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