Down-regulation of canonical and up-regulation of non-canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinoma

The majority of lung cancers (LC) belong to the non-small cell lung carcinoma (NSCLC) type. The two main NSCLC sub-types, namely adenocarcinoma (AC) and squamous cell carcinoma (SCC), respond differently to therapy. Whereas the link between cigarette smoke and lung cancer risk is well established, t...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e57393
Hauptverfasser:	Bartis, Domokos, Csongei, Veronika, Weich, Alexander, Kiss, Edit, Barko, Szilvia, Kovacs, Tamas, Avdicevic, Monika, D'Souza, Vijay K, Rapp, Judit, Kvell, Krisztian, Jakab, Laszlo, Nyitrai, Miklos, Molnar, Tamas F, Thickett, David R, Laszlo, Terezia, Pongracz, Judit E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Analysis beta Catenin - metabolism Biology Biotechnology Cadherin Cadherins Cancer Cancer research Carcinogens Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cell Line, Tumor Cell Transformation, Neoplastic - metabolism Cigarette smoke Epithelial cells Gene expression Gene Expression Regulation, Neoplastic Health aspects Health risks Humans Immunology Kinases Lung cancer Lung carcinoma Lung diseases Lung Neoplasms - genetics Lung Neoplasms - metabolism Medical schools Medicine Melanoma Metastasis Motility Non-small cell lung cancer Non-small cell lung carcinoma Nuclei Nuclei (cytology) Protein Transport Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Regulations Relocation Respiratory tract Signal transduction Signaling Skin cancer Small cell lung carcinoma Smoke Smoking Squamous cell carcinoma Surgery Target recognition Tumor cell lines Tumors Up-regulation Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism Wnt Signaling Pathway Wnt-5a Protein β-Catenin
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