Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum

This study focuses on the role of the kinase BRaf in postnatal brain development. Mice expressing truncated, non-functional BRaf in neural stem cell-derived brain tissue demonstrate alterations in the cerebellum, with decreased sizes and fuzzy borders of the glomeruli in the granule cell layer. In a...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e58259
Hauptverfasser:	Pfeiffer, Verena, Götz, Rudolf, Xiang, Chaomei, Camarero, Guadelupe, Braun, Attila, Zhang, Yina, Blum, Robert, Heinsen, Helmut, Nieswandt, Bernhard, Rapp, Ulf R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Behavior, Animal Biology Brain Brain stem Cancer Cell culture Cell cycle Cell Differentiation - genetics Cell division Cell size Cells (biology) Cellular structure Cerebellum Cerebellum - growth & development Cerebellum - metabolism Defects Dendritic structure Dentate gyrus Dentate Gyrus - growth & development Dentate Gyrus - metabolism Fitness Gene Deletion Granular materials Hippocampus Hippocampus - growth & development Hippocampus - metabolism Kinases Male Mammals Medicine Mice Mice, Transgenic Microtubule-associated protein 2 Mutation Nervous system Neural stem cells Neurobiology Neurogenesis Neurons Neurons - cytology Neurons - metabolism Neurophysiology Neurosciences Phenotype Phosphorylation Proteins Proto-Oncogene Proteins B-raf - genetics Purkinje cells Rodents Stem cells
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