Spatiotemporal dynamics of early DNA damage response proteins on complex DNA lesions

The response of cells to ionizing radiation-induced DNA double-strand breaks (DSB) is determined by the activation of multiple pathways aimed at repairing the injury and maintaining genomic integrity. Densely ionizing radiation induces complex damage consisting of different types of DNA lesions in c...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e57953
Hauptverfasser:	Tobias, Frank, Löb, Daniel, Lengert, Nicor, Durante, Marco, Drossel, Barbara, Taucher-Scholz, Gisela, Jakob, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Carcinogenesis Carcinogens Cell cycle Cell Cycle Proteins - metabolism Cell Line, Tumor Charged particles Chromatin Chromatin - genetics Chromatin - metabolism Clustering Complexity Damage accumulation Deoxyribonucleic acid DNA DNA Damage DNA Repair Double-strand break repair Fluorescence Fluorescence recovery after photobleaching Humans Impact damage Ionizing radiation Irradiation Kinases Lesions Linear Energy Transfer Maintenance Microscopy Mobility Models, Biological Nuclear Proteins - metabolism Phosphorylation Photobleaching Physics Protein interaction Protein Transport Proteins Radiation Radiation damage Radiation effects Radiation injuries Recovery (Medical) Recruitment Repair Spatio-Temporal Analysis Trans-Activators - metabolism
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