Tracking dynamic microvascular changes during healing after complete biopsy punch on the mouse pinna using optical microangiography

Optical microangiography (OMAG) and Doppler optical microangiography (DOMAG) are two non-invasive techniques capable of determining the tissue microstructural content, microvasculature angiography, and blood flow velocity and direction. These techniques were used to visualize the acute and chronic m...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e57976-e57976
Hauptverfasser:	Jung, Yeongri, Dziennis, Suzan, Zhi, Zhongwei, Reif, Roberto, Zheng, Ying, Wang, Ruikang K
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiography Angiography - methods Animals Bioengineering Biology Biopsy Biopsy - adverse effects Blood Blood flow Capillaries Diabetes Ear Auricle - surgery Feasibility Studies Flow velocity Imaging, Three-Dimensional Medical imaging Medicine Mice Microscopy Microtechnology - methods Microvasculature Microvessels - diagnostic imaging Microvessels - pathology Microvessels - physiopathology Mouse devices Optics Physics Studies Time Factors Tissues Tomography Tortuosity Tracking Ulcers Wound Healing
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Zusammenfassung:	Optical microangiography (OMAG) and Doppler optical microangiography (DOMAG) are two non-invasive techniques capable of determining the tissue microstructural content, microvasculature angiography, and blood flow velocity and direction. These techniques were used to visualize the acute and chronic microvascular and tissue responses upon an injury in vivo. A tissue wound was induced using a 0.5 mm biopsy punch on a mouse pinna. The changes in the microangiography, blood flow velocity and direction were quantified for the acute (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0057976