Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway

Immunotherapy is fast emerging as one of the leading modes of treatment of cancer, in combination with chemotherapy and radiation. Use of immunotoxins, proteins bearing a cell-surface receptor-specific antibody conjugated to a toxin, enhances the efficacy of cancer treatment. The toxin Abrin, isolat...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e58304
Hauptverfasser:	Gadadhar, Sudarshan, Karande, Anjali A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abrin - isolation & purification Abrin - pharmacology Abrus - chemistry Analysis Antibodies Antibodies, Monoclonal - pharmacology Antigens Biochemistry Biological Transport Biology Brain cancer Breast cancer Cancer Cancer therapies Catalysis Cell death Cell Line, Tumor Cell surface Chains Chemotherapy Confocal Cytometry Cytotoxicity Escherichia coli - metabolism Flow cytometry Fractionation Gonadotropins Growth factors Humans Immunoconjugates - pharmacology Immunoglobulins Immunotherapy Immunotoxins Immunotoxins - isolation & purification Immunotoxins - pharmacology Inhibition Internalization Kinetics L-leucine Leucine Localization Microscopy Molecular Targeted Therapy Monoclonal antibodies Neurohormones Nuclei Nuclei (cytology) Pituitary (anterior) Plant Extracts - pharmacology Protein biosynthesis Protein Biosynthesis - drug effects Protein purification Protein synthesis Proteins Pseudomonas Radiation Reaction kinetics Receptors, LHRH - metabolism Recombinant Proteins - pharmacology Scanning microscopy Science Toxicity Toxins Tumors
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