Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma

Mutations in the MCPH1 (microcephalin 1) gene, located at chromosome 8p23.1, result in two autosomal recessive disorders: primary microcephaly and premature chromosome condensation syndrome. MCPH1 has also been shown to be downregulated in breast, prostate and ovarian cancers, and mutated in 1/10 br...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e54643-e54643
Hauptverfasser:	Venkatesh, Thejaswini, Nagashri, Mathighatta Nagaraj, Swamy, Shivananda S, Mohiyuddin, S M Azeem, Gopinath, Kodaganur S, Kumar, Arun
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Agar Animal tissues Animals Apoptosis B cells Biology Brain Breast cancer Cancer therapies Carcinoma, Squamous Cell - genetics Cell Cycle Proteins Cell growth Cell Line, Tumor Cell Proliferation Cell size Chromosome 8 Cytoskeletal Proteins Deoxyribonucleic acid DNA DNA methylation DNA repair Endometrial cancer Endometrium Ethics Gene Expression Regulation, Neoplastic Genes Genes, Tumor Suppressor HeLa Cells Humans Ionizing radiation Loss of Heterozygosity Low level Medicine Metastasis Methylation Mice Mice, Inbred BALB C Mice, Nude Microcephaly Microencephaly MicroRNAs MicroRNAs - genetics Mouth Neoplasms - genetics Mutation Neoplasm Invasiveness Neoplasm Transplantation Nerve Tissue Proteins - genetics Oncology Oral cancer Oral squamous cell carcinoma Ovarian cancer Prostate Proteins Squamous cell carcinoma Suppressors Surgery Transcription Ts gene Tumor cell lines Tumor suppressor genes Tumors
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